DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SCF_FBW7_1

Location: 721:726

E3 ligase: FBXW7

DEGRON score: 0.9399

ASA_SCORE: 81.6667

COIL: 0.9203

CONS_SCORE: 0.3997

DSS_SCORE: 0.7794

HELIX: 0.0415

FCONS_SCORE: 0.9619

RIG_SCORE: 0.6165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F717L	TCGA-D3-A5GL	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.2222
p.L713I	TCGA-EY-A215	UCEC	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.1111
p.G720R	TCGA-FR-A3R1	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.3056
p.D724N	TCGA-GD-A3OQ	BLCA	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.6932
p.R719C	TCGA-W3-A824	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.2778
p.D722Y	TCGA-WE-AA9Y	SKCM	TCGA	PTPVNS	DEG_SCF_FBW7_1	0.7325
p.H723P	DO48393	BLCA	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.7694
p.R725H	DO22237	LGG	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.8244
p.R718W	DO49657	LIHC	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.25
p.A721V	DO222702	MELA	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.6936
p.K717R	DO220176	SARC	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.2222
p.E727D	DO37571	SKCM	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.3056
p.E727K	DO52399	UCEC	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.3056
p.L730M	DO41644	UCEC	ICGC	PTPVNS	DEG_SCF_FBW7_1	0.2222
p.R719H	SIDM00473	Oral Cavity Carcinoma	GDSC	PTPVNS	DEG_SCF_FBW7_1	0.2778
p.G730R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PTPVNS	DEG_SCF_FBW7_1	0.2222
p.G730R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.2222
p.R718S	ACH-000830	Lung Cancer	CCLE	PTPVNS	DEG_SCF_FBW7_1	0.25
p.R718S	NCI-H1436	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.25
p.P727L	NCI-H1355	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.3056
p.R713S	NCI-H1436	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.1111
p.G716R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.1944
p.R729Q	TE-9	oesophagus	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.25
p.R724H	TMK-1	stomach	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.8244
p.R724H	PC-3_[JPC-3]	lung	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.8244
p.R718Q	Hs633T	soft_tissue	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.25
p.N728H	ASH-3	thyroid	COSMIC	PTPVNS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SCF_FBW7_1	721:726	PTPVNS	FBXW7	0.9399	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPVNS

Degron related mutations and impact score

Drug responses associated with MAP3K9 mutations

All proteins holding degron of PTPVNS