DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_APCC_DBOX_1

Location: 1045:1053

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9762

ASA_SCORE: 76.0333

COIL: 0.8893

CONS_SCORE: 0.4253

DSS_SCORE: 0.5544

HELIX: 0.0661

FCONS_SCORE: 0.9888

RIG_SCORE: 0.695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1061R	TCGA-44-6777	LUAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.1111
p.S1048T	TCGA-50-5066	LUAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.7116
p.E1058D	TCGA-D3-A2JL	SKCM	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.1944
p.T1042M	TCGA-QQ-A8VF	SARC	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.25
p.V1057I	TCGA-VQ-A91K	STAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.2222
p.S1055N	TCGA-XK-AAIW	PRAD	TCGA	ERPGLPALL	DEG_APCC_DBOX_1	0.2778
p.E1050K	DO50284	SKCM	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	0.7022
p.G1051E	DO51282	SKCM	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	0.7199
p.P1059S	DO40879	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	0.1667
p.P1059L	DO43306	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	0.1667
p.C1061Y	DO41235	UCEC	ICGC	ERPGLPALL	DEG_APCC_DBOX_1	0.1111
p.T1056I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERPGLPALL	DEG_APCC_DBOX_1	0.25
p.T1056I	NCI-H1155	lung	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	0.25
p.P1062L	ACH-000937	Leukemia	CCLE	ERPGLPALL	DEG_APCC_DBOX_1	0.0833
p.P1062L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	0.0833
p.S1056N	MDA-MB-231	breast	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	0.25
p.T1042I	NCI-H1155	lung	COSMIC	ERPGLPALL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_APCC_DBOX_1	1045:1053	ERPGLPALL	APC,CDC20,FZR1	0.9762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons