DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SCF_FBW7_1

Location: 626:632

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 80.1

COIL: 0.9477

CONS_SCORE: 0.4179

DSS_SCORE: 0.6566

HELIX: 0.0261

FCONS_SCORE: 1.0064

RIG_SCORE: 0.5726

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S627I	TCGA-55-A4DG	LUAD	TCGA	LSTPSES	DEG_SCF_FBW7_1	0.623
p.S627I	DO26337	LUAD	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.623
p.E631K	SIDM00414	Bladder Carcinoma	GDSC	LSTPSES	DEG_SCF_FBW7_1	0.591
p.E631K	ACH-000545	Bladder Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	0.591
p.E631K	VM-CUB-1	urinary_tract	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.591
p.S616F	TCGA-EE-A2MT	SKCM	TCGA	LSTPSES	DEG_SCF_FBW7_1	0.5
p.S616F	DO38051	SKCM	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.5
p.K622N	DO222402	MELA	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.3333
p.K624N	DO41235	UCEC	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.2778
p.H634D	SIDM00242	Osteosarcoma	GDSC	LSTPSES	DEG_SCF_FBW7_1	0.2778
p.H634D	ACH-002067	Bone Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	0.2778
p.H634D	NOS-1	bone	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.2778
p.T635I	ACH-001515	Cervical Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	0.25
p.E621V	TCGA-F7-A623	HNSC	TCGA	LSTPSES	DEG_SCF_FBW7_1	0.1944
p.E621V	DO44443	HNSC	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.1944
p.L637S	DO227987	COCA	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.1944
p.N620Y	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.1667
p.E619Q	ACH-000975	Lung Cancer	CCLE	LSTPSES	DEG_SCF_FBW7_1	0.1389
p.E619Q	H513	pleura	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.1389
p.Q618R	DO229234	THCA	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.1111
p.P617T	TCGA-50-6673	LUAD	TCGA	LSTPSES	DEG_SCF_FBW7_1	0.0833
p.P617T	DO24218	LUAD	ICGC	LSTPSES	DEG_SCF_FBW7_1	0.0833
p.R642Q	SW1783	central_nervous_system	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.0556
p.R642W	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPSES	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SCF_FBW7_1	626:632	LSTPSES	FBXW7	0.9965	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons