DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SCF_FBW7_1

Location: 562:569

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 74.55

COIL: 0.7348

CONS_SCORE: 0.4277

DSS_SCORE: 0.559

HELIX: 0.0814

FCONS_SCORE: 0.9678

RIG_SCORE: 0.6509

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R558C	TCGA-59-2349	OV	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.R558C	DO28621	OV	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.W573C	TCGA-AB-2833	LAML	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.W573C	DO21679	LAML	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.T572P	TCGA-CG-4460	STAD	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.25
p.T572P	DO38427	STAD	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.25
p.R558H	TCGA-CG-4460	STAD	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.R558H	DO38427	STAD	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.2222
p.R560L	TCGA-D3-A2JP	SKCM	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.2778
p.R560L	DO47407	SKCM	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.2778
p.P557S	TCGA-GN-A266	SKCM	TCGA	IQLTPGES	DEG_SCF_FBW7_1	0.1944
p.P557S	DO37432	SKCM	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.1944
p.P557T	DO228986	LICA	ICGC	IQLTPGES	DEG_SCF_FBW7_1	0.1944
p.V579I	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.V579I	SIDM01155	Glioma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.V579I	SW1088	central_nervous_system	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.V579I	NCI-H1869	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.V579F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.V579F	Calu-6	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.0556
p.N577Y	ACH-000754	Lymphoma	CCLE	IQLTPGES	DEG_SCF_FBW7_1	0.1111
p.N577Y	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.1111
p.D560E	ACH-000921	Lung Cancer	CCLE	IQLTPGES	DEG_SCF_FBW7_1	0.2778
p.N572Y	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.25
p.R570W	SW1783	central_nervous_system	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.3056
p.R570W	NCI-H1155	lung	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.3056
p.R570W	HEC-1	endometrium	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.3056
p.R564W	KYSE-450	oesophagus	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.8634
p.A563V	OVCA420	ovary	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.6936
p.R569T	FADU	upper_aerodigestive_tract	COSMIC	IQLTPGES	DEG_SCF_FBW7_1	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQLTPGES

Degron related mutations and impact score

Drug responses associated with MAP3K9 mutations

All proteins holding degron of IQLTPGES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SCF_FBW7_1	562:569	IQLTPGES	FBXW7	0.9955	More...