DegronMD

Uniprot ID: P80192

Source protein: Mitogen-activated protein kinase kinase kinase 9

Source gene: MAP3K9

Class: DEG_SCF_FBW7_1

Location: 945:952

E3 ligase: FBXW7

DEGRON score: 0.9668

ASA_SCORE: 81.6375

COIL: 0.8661

CONS_SCORE: 0.4415

DSS_SCORE: 0.7465

HELIX: 0.0249

FCONS_SCORE: 0.9782

RIG_SCORE: 0.5399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S954N	TCGA-B5-A3FA	UCEC	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	0.2778
p.A942T	TCGA-BG-A222	UCEC	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	0.25
p.L951F	TCGA-C8-A275	BRCA	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	0.6981
p.S945N	TCGA-D3-A8GI	SKCM	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	0.7069
p.G956V	TCGA-ER-A1A1	SKCM	TCGA	MLKTPSPS	DEG_SCF_FBW7_1	0.2222
p.P936A	DO3852	BRCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.0833
p.R937H	DO219054	HNSC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.1111
p.N953K	DO229025	LICA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.3056
p.R950W	DO222911	MELA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.8634
p.D957G	DO232761	PBCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.1944
p.L938F	DO229446	SKCA	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.5833
p.R951H	DO43682	UCEC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.8244
p.F935L	DO41488	UCEC	ICGC	MLKTPSPS	DEG_SCF_FBW7_1	0.0556
p.P947A	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.7503
p.E938G	HGC-27	stomach	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.5833
p.P962L	GP5d	large_intestine	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.0556
p.R953Q	TE-9	oesophagus	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.3056
p.R962S	NCI-H1436	lung	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.0556
p.P939L	GP5d	large_intestine	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.1667
p.P951L	NCI-H1355	lung	COSMIC	MLKTPSPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SCF_FBW7_1	945:952	MLKTPSPS	FBXW7	0.9668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons