DegronMD

Degron: NPIRAYTPPP

Uniprot ID: P42694

Source protein: Probable helicase with zinc finger domain

Source gene: HELZ

Class: CBL_PTK

Location: 1157:1166

E3 ligase: CBL

DEGRON score: 0.9944

ASA_SCORE: 64.07

COIL: 0.8957

CONS_SCORE: 0.5575

DSS_SCORE: 0.6237

HELIX: 0.0332

FCONS_SCORE: 0.9845

RIG_SCORE: 0.6486

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1161T	DO508	BLCA	ICGC	NPIRAYTPPP	CBL_PTK	0.7876
p.R1160T	TCGA-C4-A0F6	BLCA	TCGA	NPIRAYTPPP	CBL_PTK	0.6765
p.P1165Q	DO229009	LICA	ICGC	NPIRAYTPPP	CBL_PTK	0.5924
p.I1155T	TCGA-32-1977	GBM	TCGA	NPIRAYTPPP	CBL_PTK	0.2778
p.I1155T	DO12076	GBM	ICGC	NPIRAYTPPP	CBL_PTK	0.2778
p.L1168F	TCGA-CV-7568	HNSC	TCGA	NPIRAYTPPP	CBL_PTK	0.2778
p.L1168V	TCGA-DK-A6B6	BLCA	TCGA	NPIRAYTPPP	CBL_PTK	0.2778
p.L1168V	DO48576	BLCA	ICGC	NPIRAYTPPP	CBL_PTK	0.2778
p.L1169F	DO14160	HNSC	ICGC	NPIRAYTPPP	CBL_PTK	0.25
p.P1152S	DO37782	SKCM	ICGC	NPIRAYTPPP	CBL_PTK	0.1944
p.P1151H	TCGA-FS-A1ZN	SKCM	TCGA	NPIRAYTPPP	CBL_PTK	0.1667
p.P1151H	DO38165	SKCM	ICGC	NPIRAYTPPP	CBL_PTK	0.1667
p.P1151S	TCGA-GN-A26C	SKCM	TCGA	NPIRAYTPPP	CBL_PTK	0.1667
p.H1172Q	DO228971	LICA	ICGC	NPIRAYTPPP	CBL_PTK	0.1667
p.H1172Y	SIDM00539	Esophageal Carcinoma	GDSC	NPIRAYTPPP	CBL_PTK	0.1667
p.P1173T	DO229024	LICA	ICGC	NPIRAYTPPP	CBL_PTK	0.1389
p.Q1148K	DO228985	LICA	ICGC	NPIRAYTPPP	CBL_PTK	0.0833

Showing 1 to 17 of 17 entries

Drug responses associated with HELZ mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of NPIRAYTPPP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42694	Probable helicase with zinc finger domain	CBL_PTK	1157:1166	NPIRAYTPPP	CBL	0.9944	More...

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