DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPIRAYTPPP
Uniprot ID:
P42694
Source protein:
Probable helicase with zinc finger domain
Source gene:
HELZ
Class:
CBL_PTK
Location:
1157:1166
E3 ligase:
CBL
DEGRON score:
0.9944
ASA_SCORE:
64.07
COIL:
0.8957
CONS_SCORE:
0.5575
DSS_SCORE:
0.6237
HELIX:
0.0332
FCONS_SCORE:
0.9845
RIG_SCORE:
0.6486
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I1155T
TCGA-32-1977
GBM
TCGA
NPIRAYTPPP
CBL_PTK
0.2778
p.I1155T
DO12076
GBM
ICGC
NPIRAYTPPP
CBL_PTK
0.2778
p.R1160T
TCGA-C4-A0F6
BLCA
TCGA
NPIRAYTPPP
CBL_PTK
0.6765
p.L1168F
TCGA-CV-7568
HNSC
TCGA
NPIRAYTPPP
CBL_PTK
0.2778
p.L1168V
TCGA-DK-A6B6
BLCA
TCGA
NPIRAYTPPP
CBL_PTK
0.2778
p.L1168V
DO48576
BLCA
ICGC
NPIRAYTPPP
CBL_PTK
0.2778
p.P1151H
TCGA-FS-A1ZN
SKCM
TCGA
NPIRAYTPPP
CBL_PTK
0.1667
p.P1151H
DO38165
SKCM
ICGC
NPIRAYTPPP
CBL_PTK
0.1667
p.P1151S
TCGA-GN-A26C
SKCM
TCGA
NPIRAYTPPP
CBL_PTK
0.1667
p.R1161T
DO508
BLCA
ICGC
NPIRAYTPPP
CBL_PTK
0.7876
p.L1169F
DO14160
HNSC
ICGC
NPIRAYTPPP
CBL_PTK
0.25
p.H1172Q
DO228971
LICA
ICGC
NPIRAYTPPP
CBL_PTK
0.1667
p.Q1148K
DO228985
LICA
ICGC
NPIRAYTPPP
CBL_PTK
0.0833
p.P1173T
DO229024
LICA
ICGC
NPIRAYTPPP
CBL_PTK
0.1389
p.P1165Q
DO229009
LICA
ICGC
NPIRAYTPPP
CBL_PTK
0.5924
p.P1152S
DO37782
SKCM
ICGC
NPIRAYTPPP
CBL_PTK
0.1944
p.H1172Y
SIDM00539
Esophageal Carcinoma
GDSC
NPIRAYTPPP
CBL_PTK
0.1667
Drug responses associated with HELZ mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPIRAYTPPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P42694
Probable helicase with zinc finger domain
CBL_PTK
1157:1166
NPIRAYTPPP
CBL
0.9944
More...
