DegronMD

Uniprot ID: P42694

Source protein: Probable helicase with zinc finger domain

Source gene: HELZ

Class: DEG_COP1_1

Location: 1612:1621

E3 ligase: COP1

DEGRON score: 0.996

ASA_SCORE: 89.95

COIL: 0.974

CONS_SCORE: 0.5181

DSS_SCORE: 0.774

HELIX: 0.0105

FCONS_SCORE: 1.1214

RIG_SCORE: 0.5112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1604R	TCGA-06-5416	GBM	TCGA	SRSPPAVPSP	DEG_COP1_1	0.1111
p.S1614R	TCGA-AN-A0XN	BRCA	TCGA	SRSPPAVPSP	DEG_COP1_1	0.8538
p.S1614R	DO3745	BRCA	ICGC	SRSPPAVPSP	DEG_COP1_1	0.8538
p.S1614R	DO229032	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	0.8538
p.V1610I	TCGA-AX-A1C4	UCEC	TCGA	SRSPPAVPSP	DEG_COP1_1	0.2778
p.L1605R	DO10880	GBM	ICGC	SRSPPAVPSP	DEG_COP1_1	0.1389
p.H1627N	DO228986	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	0.1667
p.H1628Q	DO229027	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	0.1389
p.A1617E	DO229038	LICA	ICGC	SRSPPAVPSP	DEG_COP1_1	0.659
p.V1611I	DO42480	UCEC	ICGC	SRSPPAVPSP	DEG_COP1_1	0.3056
p.A1617T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SRSPPAVPSP	DEG_COP1_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42694	Probable helicase with zinc finger domain	DEG_COP1_1	1612:1621	SRSPPAVPSP	COP1	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons