DegronMD

Uniprot ID: P42694

Source protein: Probable helicase with zinc finger domain

Source gene: HELZ

Class: DEG_ODPH_VHL_1

Location: 1103:1114

E3 ligase: VHL

DEGRON score: 0.9693

ASA_SCORE: 67.6583

COIL: 0.624

CONS_SCORE: 0.8765

DSS_SCORE: 0.3926

HELIX: 0.3073

FCONS_SCORE: 1.2778

RIG_SCORE: 0.7849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1102L	TCGA-AX-A2HD	UCEC	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.3056
p.K1095N	TCGA-B5-A1MR	UCEC	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.5556
p.T1120A	TCGA-CG-5721	STAD	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.1667
p.A1111V	TCGA-EB-A24D	SKCM	TCGA	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.5825
p.A1111V	DO37440	SKCM	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.5825
p.A1104T	DO233941	GACA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.7139
p.S1120R	DO229346	LAML	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.1667
p.Q1124K	DO228985	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.0556
p.H1116N	DO229029	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.2778
p.H1116N	DO229026	LICA	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.2778
p.L1113V	DO23462	LINC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.6765
p.R1110G	DO45049	LINC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.6457
p.T1121A	DO38192	STAD	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.1389
p.K1096N	DO41758	UCEC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.5833
p.P1103L	DO42608	UCEC	ICGC	LAPEFIPRALRL	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42694	Probable helicase with zinc finger domain	DEG_ODPH_VHL_1	1103:1114	LAPEFIPRALRL	VHL	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons