TICAM1
UniProt ID: Q8IUC6
Entrez ID: 148022
Protein name: TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding...
FUNCTION: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis (PubMed:12471095, PubMed:12539043, PubMed:14739303, PubMed:28747347). Ligand binding to these receptors results in TRIF recruitment through its TIR domain (PubMed:12471095, PubMed:12539043, PubMed:14739303). Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively (PubMed:12471095, PubMed:12539043, PubMed:14739303). Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (PubMed:25636800). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303, ECO:0000269|PubMed:25636800}.
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GO - Biological processes (BP):
apoptotic signaling pathway [GO:0097190]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipop...
apoptotic signaling pathway [GO:0097190]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein-containing complex assembly [GO:0043254]; response to exogenous dsRNA [GO:0043330]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]
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GO - Molecular function (MF):
NAD+ nucleosidase activity [GO:0003953]; protein kinase binding [GO:0019901]...
NAD+ nucleosidase activity [GO:0003953]; protein kinase binding [GO:0019901]
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GO - Cellular component (CC):
autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342]...
autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342]
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TICAM1
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*NOTE: the Kaplan plots were collected from OncoLnc