DegronMD

Uniprot ID: Q8IUC6

Source protein: TIR domain-containing adapter molecule 1

Source gene: TICAM1

Class: DEG_SCF_FBW7_1

Location: 353:359

E3 ligase: FBXW7

DEGRON score: 0.6825

ASA_SCORE: 107.7429

COIL: 0.9717

CONS_SCORE: 0.3825

DSS_SCORE: 0.7487

HELIX: 0.0093

FCONS_SCORE: 0.9686

RIG_SCORE: 0.4873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P360S	TCGA-28-1755	GBM	TCGA	PTTPETS	DEG_SCF_FBW7_1	0.3056
p.P360S	DO13366	GBM	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.3056
p.C349W	TCGA-44-7662	LUAD	TCGA	PTTPETS	DEG_SCF_FBW7_1	0.2222
p.C349W	DO23597	LUAD	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.2222
p.P348L	TCGA-AX-A06F	UCEC	TCGA	PTTPETS	DEG_SCF_FBW7_1	0.1944
p.P348L	DO41752	UCEC	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.1944
p.T354I	TCGA-BS-A0TJ	UCEC	TCGA	PTTPETS	DEG_SCF_FBW7_1	0.5966
p.T354I	DO42953	UCEC	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.5966
p.P360L	TCGA-FW-A3R5	SKCM	TCGA	PTTPETS	DEG_SCF_FBW7_1	0.3056
p.P360L	DO37406	SKCM	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.3056
p.P356S	DO52436	COCA	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.6752
p.S359P	DO233782	GACA	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.6752
p.E357Q	DO229266	LMS	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.5633
p.P353H	DO233293	NACA	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.7694
p.P364L	DO229453	SKCA	ICGC	PTTPETS	DEG_SCF_FBW7_1	0.1944
p.T346I	SIDM00852	Glioma	GDSC	PTTPETS	DEG_SCF_FBW7_1	0.1389
p.T346I	ACH-000389	Brain Cancer	CCLE	PTTPETS	DEG_SCF_FBW7_1	0.1389
p.T346I	H4	central_nervous_system	COSMIC	PTTPETS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUC6	TIR domain-containing adapter molecule 1	DEG_SCF_FBW7_1	353:359	PTTPETS	FBXW7	0.6825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons