DegronMD

Uniprot ID: Q8N8W4

Source protein: Omega-hydroxyceramide transacylase

Source gene: PNPLA1

Class: DEG_SCF_FBW7_1

Location: 381:388

E3 ligase: FBXW7

DEGRON score: 0.9521

ASA_SCORE: 71.325

COIL: 0.9301

CONS_SCORE: 0.2559

DSS_SCORE: 0.7319

HELIX: 0.0135

FCONS_SCORE: 0.9226

RIG_SCORE: 0.4618

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T391P	TCGA-19-5956	GBM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.25
p.P390H	TCGA-49-AAR9	LUAD	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.2778
p.P381L	TCGA-4Z-AA84	BLCA	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.6471
p.K379R	TCGA-AZ-4315	COAD	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.2778
p.P371L	TCGA-BF-AAP2	SKCM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.0556
p.P392S	TCGA-DU-6407	LGG	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.2222
p.G395R	TCGA-EE-A20C	SKCM	TCGA	PSSTPGSS	DEG_SCF_FBW7_1	0.1389
p.A388D	DO10647	COAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.7793
p.V398I	DO233855	GACA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.0556
p.V398I	D-392MG	central_nervous_system	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.0556
p.V389L	DO229028	LICA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.V389L	DO25123	LUAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.S387I	DO229024	LICA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.623
p.V389M	DO231708	LINC	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.Q373H	DO46869	RECA	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.1111
p.H393Y	DO222372	STAD	ICGC	PSSTPGSS	DEG_SCF_FBW7_1	0.1944
p.L389P	SIDM00773	Non-Cancerous	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM01126	Small Cell Lung Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM00690	Head and Neck Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM00210	Ovarian Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM00774	Breast Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM01173	Rhabdomyosarcoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.L389P	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.V372I	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.0833
p.V372I	TE-11	oesophagus	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.0833
p.S388L	SIDM00149	Melanoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.7667
p.S388L	LOXIMVI	skin	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.7667
p.A376V	SIDM01000	Melanoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.1944
p.A376V	WM-115	skin	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.1944
p.P393T	SIDM01318	Hepatocellular Carcinoma	GDSC	PSSTPGSS	DEG_SCF_FBW7_1	0.1944
p.V389I	D-392MG	central_nervous_system	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.3056
p.A388T	CHP-212	autonomic_ganglia	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.7139
p.A379T	CHP-212	autonomic_ganglia	COSMIC	PSSTPGSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8W4	Omega-hydroxyceramide transacylase	DEG_SCF_FBW7_1	381:388	PSSTPGSS	FBXW7	0.9521	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SCF_FBW7_1	10:17	PSSTPGSS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPGSS

Degron related mutations and impact score

Drug responses associated with PNPLA1 mutations

All proteins holding degron of PSSTPGSS