DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSSTPGSS
Uniprot ID:
O75956
Source protein:
Cyclin-dependent kinase 2-associated protein 2
Source gene:
CDK2AP2
Class:
DEG_SCF_FBW7_1
Location:
10:17
E3 ligase:
FBXW7
DEGRON score:
0.9989
ASA_SCORE:
81.375
COIL:
0.9704
CONS_SCORE:
0.5567
DSS_SCORE:
0.6748
HELIX:
0.013
FCONS_SCORE:
1.1415
RIG_SCORE:
0.4758
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S12I
TCGA-EO-A22U
UCEC
TCGA
PSSTPGSS
DEG_SCF_FBW7_1
0.623
p.S12I
DO43755
UCEC
ICGC
PSSTPGSS
DEG_SCF_FBW7_1
0.623
Drug responses associated with CDK2AP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSSTPGSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N8W4
Omega-hydroxyceramide transacylase
DEG_SCF_FBW7_1
381:388
PSSTPGSS
FBXW7
0.9521
More...
O75956
Cyclin-dependent kinase 2-associated protein 2
DEG_SCF_FBW7_1
10:17
PSSTPGSS
FBXW7
0.9989
More...