DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 883:887

E3 ligase: SPOP

DEGRON score: 0.9896

ASA_SCORE: 83.46

COIL: 0.9624

CONS_SCORE: 0.6133

DSS_SCORE: 0.6915

HELIX: 0.0122

FCONS_SCORE: 1.1079

RIG_SCORE: 0.6121

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S887F	TCGA-3N-A9WC	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	TCGA-ER-A195	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	TCGA-FR-A8YC	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	TCGA-WE-A8K5	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	DO50301	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	DO47712	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	DO51282	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	DO51234	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	SIDM00007	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	ACH-001550	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.7982
p.S887F	MCC13	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7982
p.P883T	TCGA-CR-7388	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7031
p.P883T	DO14284	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7031
p.P876S	TCGA-EE-A29D	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876S	DO229446	SKCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876S	DO218849	SKCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876S	DO38123	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894E	TCGA-EE-A29D	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894E	DO38123	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894R	TCGA-EE-A3AG	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894R	DO37471	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894R	SIDM00545	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894R	ACH-000987	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.1389
p.G894R	Mewo	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876L	TCGA-GN-A266	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876L	DO37432	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876L	SIDM01397	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P876L	ACH-000765	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.1389
p.A879T	DO225386	BRCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.F875C	DO222884	COCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.T884A	DO50446	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7139
p.R882I	DO234225	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.3056
p.F875V	DO233840	GACA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.F875L	DO45299	LIRI	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.D880E	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.25
p.D880E	ACH-000858	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.25
p.D880E	KNS-62	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.25
p.I896V	ACH-001032	Bone Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTS

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PTTTS