DegronMD - A1A4S6(ARHGAP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R575Q	TCGA-06-6695	GBM	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.6218
p.R575Q	DO13540	GBM	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.6218
p.S683F	TCGA-B5-A11E	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0556
p.S683F	DO41644	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0556
p.T695I	TCGA-DI-A1BU	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7078
p.T695I	DO42023	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7078
p.R575W	TCGA-EE-A3AH	SKCM	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.7523
p.R575W	DO222635	MELA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.7523
p.R575W	DO35083	PACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.7523
p.R575W	DO37443	SKCM	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.7523
p.D579N	TCGA-EY-A1GH	UCEC	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.5821
p.D579N	DO40972	UCEC	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.5821
p.P693T	TCGA-FI-A2D5	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7031
p.P693T	DO41331	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation altering degron motif	0.7031
p.S706L	TCGA-YD-A9TA	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833
p.S706L	DO219503	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.0833
p.S700L	TCGA-YG-AA3O	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.25
p.S700L	DO51299	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.25
p.L688F	DO234154	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1944
p.S692F	DO234443	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.3056
p.P577S	DO228546	LICA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation altering degron motif	0.6752
p.T581A	DO232835	NACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation rewiring degron network	0.3056
p.P583H	DO232838	NACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	573:580	Mutation rewiring degron network	0.25
p.T703A	SIDM01090	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.T703A	SIDM00309	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.1667
p.S698P	ACH-000628	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.3056
p.S698P	NCI-H596	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.3056
p.N689I	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2222
p.N689I	NCI-H630	large intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	693:697	Mutation rewiring degron network	0.2222

Kaplan plot for ARHGAP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP10

UniProt ID: A1A4S6

Entrez ID: 79658

Protein name: Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP10 in