DegronMD

Uniprot ID: A1A4S6

Source protein: Rho GTPase-activating protein 10

Source gene: ARHGAP10

Class: DEG_SCF_FBW7_1

Location: 573:580

E3 ligase: FBXW7

DEGRON score: 0.9209

ASA_SCORE: 90.1625

COIL: 0.8183

CONS_SCORE: 0.4381

DSS_SCORE: 0.5146

HELIX: 0.1078

FCONS_SCORE: 0.9023

RIG_SCORE: 0.7158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R575Q	TCGA-06-6695	GBM	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	0.6218
p.R575Q	DO13540	GBM	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.6218
p.R575W	TCGA-EE-A3AH	SKCM	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	0.7523
p.R575W	DO222635	MELA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.7523
p.R575W	DO35083	PACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.7523
p.R575W	DO37443	SKCM	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.7523
p.D579N	TCGA-EY-A1GH	UCEC	TCGA	IFRTPPDT	DEG_SCF_FBW7_1	0.5821
p.D579N	DO40972	UCEC	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.5821
p.P577S	DO228546	LICA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.6752
p.T581A	DO232835	NACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.3056
p.P583H	DO232838	NACA	ICGC	IFRTPPDT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SCF_FBW7_1	573:580	IFRTPPDT	FBXW7	0.9209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons