DegronMD

Uniprot ID: Q96HA1

Source protein: Nuclear envelope pore membrane protein POM 121

Source gene: POM121

Class: DEG_SPOP_SBC_1

Location: 761:765

E3 ligase: SPOP

DEGRON score: 0.9806

ASA_SCORE: 84.76

COIL: 0.9406

CONS_SCORE: 0.5576

DSS_SCORE: 0.6321

HELIX: 0.019

FCONS_SCORE: 0.9649

RIG_SCORE: 0.6174

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T769M	TCGA-21-1076	LUSC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.2222
p.T769M	DO26599	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.H762Q	TCGA-29-1763	OV	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	DO231075	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	DO28422	OV	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00557	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00266	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00690	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00489	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00815	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00254	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00875	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00793	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00720	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.H762Q	SIDM00168	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.G767S	TCGA-AA-3672	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.2778
p.G767S	DO9010	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2778
p.G767S	J82	urinary_tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.2778
p.G766D	TCGA-AJ-A3EK	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.3056
p.G766D	DO41584	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.3056
p.S771L	TCGA-AX-A2HA	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S771L	TCGA-BA-6871	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S771L	DO15254	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S771L	DO42504	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.P763A	TCGA-B8-5164	KIRC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7503
p.P763A	DO17018	KIRC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7503
p.S771W	TCGA-CV-A45Q	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1667
p.S771W	DO49060	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1667
p.V753M	TCGA-WS-AB45	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1111
p.V753M	DO51734	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.I764T	DO231075	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00690	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00489	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00254	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00875	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00793	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00720	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	SIDM00168	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	NCI-H28	pleura	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	NCI-H250	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	HCC1806	breast	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	Ca9-22	upper_aerodigestive_tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	JHU-029	upper_aerodigestive_tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	ZR-75-30	breast	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.I764T	HCC-15	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.7078
p.A768D	DO33208	PACA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.25
p.T769A	SIDM00680	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.T769A	ACH-000957	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.2222
p.T769A	LS-180	large_intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.2222
p.P760L	SIDM00140	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.3056
p.P760L	ACH-000968	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.3056
p.P760L	COLO-792	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTS

Degron related mutations and impact score

Drug responses associated with POM121 mutations

All proteins holding degron of PTTTS