DegronMD

Uniprot ID: A6NF01

Source protein: Putative nuclear envelope pore membrane protein POM 121B

Source gene: POM121B

Class: DEG_SPOP_SBC_1

Location: 345:349

E3 ligase: SPOP

DEGRON score: 0.9532

ASA_SCORE: 88.74

COIL: 0.9526

CONS_SCORE: 0.0913

DSS_SCORE: 0.628

HELIX: 0.0164

FCONS_SCORE: 0.2855

RIG_SCORE: 0.6063

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...

Showing 1 to 14 of 14 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons