DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 197:201

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 81.52

COIL: 0.7418

CONS_SCORE: 0.4787

DSS_SCORE: 0.4854

HELIX: 0.0158

FCONS_SCORE: 1.4956

RIG_SCORE: 0.7397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T199A	TCGA-44-8117	LUAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7139
p.T199A	DO24028	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7139
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1111
p.S189I	DO41488	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1111
p.V208I	TCGA-EB-A431	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.1389
p.V208I	DO37671	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.1389
p.P197L	TCGA-EE-A3JD	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7582
p.P197L	DO50299	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7582
p.P197Q	TCGA-MP-A4TA	LUAD	TCGA	PTTTS	DEG_SPOP_SBC_1	0.7035
p.P197Q	DO45314	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7035
p.S201N	DO222501	COCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7069
p.S195R	DO223007	ESCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.2778
p.T200R	DO229250	THCA	ICGC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01137	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00331	B-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00524	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00630	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00625	Other Sarcomas	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01233	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01183	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01062	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00789	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00643	Non-Cancerous	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00200	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00885	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00269	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01168	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00057	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00474	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00719	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01044	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00568	Gastric Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00092	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00879	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01110	Hepatocellular Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00391	Plasma Cell Myeloma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00767	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00342	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00259	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01185	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00893	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00989	Bladder Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01061	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00469	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00218	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00685	Glioblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01193	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00986	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00213	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00528	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01083	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00519	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00774	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00760	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00184	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00628	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01629	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01682	Gastric Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01412	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01394	Kidney Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01752	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM01587	Bladder Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T200R	SIDM00497	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.7876
p.T210A	SIDM00120	Prostate Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	0.0833
p.T210A	ACH-000979	Prostate Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	0.0833
p.T210A	DU-145	prostate	COSMIC	PTTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A4S6	Rho GTPase-activating protein 10	DEG_SPOP_SBC_1	693:697	PTTTS	SPOP	0.9308	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	738:742	PTTTS	SPOP	0.9721	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	81:85	PTTTS	SPOP	0.9583	More...
Q6ZSS7	Major facilitator superfamily domain-containing protein 6	DEG_SPOP_SBC_1	424:428	PTTTS	SPOP	0.5073	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	197:201	PTTTS	SPOP	0.9976	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	761:765	PTTTS	SPOP	0.9806	More...
Q9H987	Synaptopodin 2-like protein	DEG_SPOP_SBC_1	480:484	PTTTS	SPOP	0.9703	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	883:887	PTTTS	SPOP	0.9896	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	40:44	PTTTS	SPOP	0.8075	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	61:65	PTTTS	SPOP	0.9973	More...
Q9Y618	Nuclear receptor corepressor 2	DEG_SPOP_SBC_1	1788:1792	PTTTS	SPOP	0.9962	More...
Q5T0B9	Zinc finger protein 362	DEG_SPOP_SBC_1	148:152	PTTTS	SPOP	0.9988	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	345:349	PTTTS	SPOP	0.9532	More...
Q5T0Z8	Uncharacterized protein C6orf132	DEG_SPOP_SBC_1	699:703	PTTTS	SPOP	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTS

Degron related mutations and impact score

Drug responses associated with HAVCR1 mutations

All proteins holding degron of PTTTS