DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 1046:1050

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 77.44

COIL: 0.9048

CONS_SCORE: 0.8563

DSS_SCORE: 0.6016

HELIX: 0.0218

FCONS_SCORE: 1.4367

RIG_SCORE: 0.6678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1057G	TCGA-66-2791	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1389
p.A1057G	DO26435	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.Q1040K	TCGA-96-7544	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1667
p.Q1040K	DO26425	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1667
p.S1047N	TCGA-BS-A0UF	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.5958
p.S1047N	DO41488	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.5958
p.Q1042H	TCGA-CQ-5334	HNSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2222
p.Q1042H	DO16053	HNSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.Q1042H	SIDM01318	Hepatocellular Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.G1044E	TCGA-EE-A2MT	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2778
p.G1044E	DO38051	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.T1045I	DO50847	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.G1041E	DO231897	LINC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G1041E	ACH-001856	Bile Duct Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1944
p.W1059L	DO230525	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.L1036F	SIDM00061	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00189	Melanoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00427	Ewing's Sarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01168	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00156	Neuroblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00095	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00090	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00027	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00865	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01185	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01051	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01102	Non-Cancerous	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00814	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01135	Pancreatic Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01084	Osteosarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01128	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L1036F	SIDM01475	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.I1038T	SIDM01696	Mesothelioma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.I1038T	ACH-000645	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PSTTS