DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_SPOP_SBC_1

Location: 674:678

E3 ligase: SPOP

DEGRON score: 0.9729

ASA_SCORE: 82.88

COIL: 0.9338

CONS_SCORE: 0.4728

DSS_SCORE: 0.5316

HELIX: 0.0338

FCONS_SCORE: 1.1081

RIG_SCORE: 0.6532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S665F	TCGA-77-A5G3	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.5278
p.S665F	DO45456	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.5278
p.C679Y	TCGA-AP-A1DK	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.3056
p.C679Y	DO42033	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.T686A	TCGA-F7-A624	HNSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1111
p.T686A	DO44440	HNSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.P684Q	DO222769	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1667
p.P671H	DO229019	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.P667Q	DO229028	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.A666D	DO229045	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.P672Q	DO229009	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.A681T	DO231043	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.P684R	DO27255	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1667
p.R670Q	DO43306	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.T677S	SIDM01314	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.6005
p.L667I	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.L667I	SIDM00954	Breast Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.L667I	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with UBAP2 mutations

All proteins holding degron of PSTTS