DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 800:804

E3 ligase: SPOP

DEGRON score: 0.9364

ASA_SCORE: 87.04

COIL: 0.933

CONS_SCORE: 0

DSS_SCORE: 0.6699

HELIX: 0.0128

FCONS_SCORE: 0

RIG_SCORE: 0.5888

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T793P	DO228483	BRCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	ACH-000247	Gastric Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	ACH-000478	Liver Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	ACH-001655	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	OCUM-1	stomach	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	KP-N-YN	autonomic_ganglia	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	SKN	soft_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.T793P	SNU-387	liver	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.P791H	DO7801	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P800L	DO222575	ESCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.P800L	DO229053	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.P800L	DO229055	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.S807R	DO229050	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.I811T	DO229063	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.P812Q	DO50889	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.P808S	DO231043	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.S809R	DO42400	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.6389
p.G812S	SIDM01269	Esophageal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.T807M	SIDM00611	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00602	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM01005	Acute Myeloid Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00569	Osteosarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00687	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00487	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00564	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00574	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00280	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00373	Endometrial Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00579	Neuroblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.T807M	SIDM00435	Acute Myeloid Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.25
p.L791V	SIDM00474	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.E806G	SIDM00131	Glioma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.E806G	CCF-STTG1	central_nervous_system	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.T802K	ACH-000247	Gastric Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-000479	Brain Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-000843	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-000941	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	ACH-001609	Brain Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	HEC-1	endometrium	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	KNS-81-FD	central_nervous_system	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	OCUM-1	stomach	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7306
p.T802K	HARA	lung	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7306
p.P790H	ACH-000989	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P790H	SNU-175	large_intestine	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.V798A	ACH-001277	Sarcoma	CCLE	PSTTS	DEG_SPOP_SBC_1	0.2778
p.V798A	ACH-002021	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.2778
p.P791T	ACH-002042	Thyroid Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.0833
p.E799K	ACH-002396	Bone Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.3056
p.E799K	Sarc9371	bone	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.S804F	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7982
p.P808A	CCF-STTG1	central_nervous_system	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.P808Q	NCI-H2342	lung	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.S801F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of PSTTS