DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1196:1200

E3 ligase: SPOP

DEGRON score: 0.9172

ASA_SCORE: 85.74

COIL: 0.86

CONS_SCORE: 0

DSS_SCORE: 0.5625

HELIX: 0.0154

FCONS_SCORE: 0

RIG_SCORE: 0.6922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1203A	TCGA-05-4403	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.25
p.P1203A	DO23631	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.S1200Y	TCGA-05-5425	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.712
p.S1200Y	DO26270	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.712
p.T1198M	TCGA-41-3393	GBM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.8534
p.T1198M	TCGA-AJ-A8CW	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.8534
p.T1198M	DO12646	GBM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.8534
p.T1198M	DO52400	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.8534
p.M1192I	TCGA-55-A494	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2222
p.M1192I	DO23794	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.L1195V	TCGA-85-8666	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.3056
p.L1195V	DO45547	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.T1187S	TCGA-AA-A01P	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0833
p.T1187S	DO8642	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P1193L	TCGA-FR-A3YO	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.25
p.P1193L	DO37419	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.E1186K	TCGA-ZF-A9RG	BLCA	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0556
p.E1186K	DO219076	BLCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P1196L	DO222868	MELA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.R1189Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.R1189Q	ACH-000953	Leukemia	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1389
p.R1189Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PSTTS