DegronMD - Q76I76(SSH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H1226R	TCGA-AA-A00N	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	1213:1217	Mutation rewiring degron network	0.0833
p.S706I	TCGA-B5-A1MR	UCEC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation blocking phosphorylation signal	0.6944
p.E724G	TCGA-D1-A163	UCEC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1111
p.M721I	TCGA-EA-A410	CESC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1944
p.R715Q	DO48566	BLCA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation altering degron motif	0.7329
p.G708E	DO225334	BRCA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.3056
p.A722S	DO228815	LICA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1667
p.D1221E	DO229018	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	1213:1217	Mutation rewiring degron network	0.2222
p.D24E	DO229026	LICA	ICGC	PTPSTT	DEG_SCF_FBW7_1	10:15	Mutation rewiring degron network	0.0833
p.D24E	DO229026	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.1111
p.T1078S	DO24487	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.3056
p.R1089K	DO46344	OV	ICGC	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.M703I	DO32516	OV	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1667
p.M703I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1667
p.M703I	KYSE-50	oesophagus	COSMIC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1667
p.S13N	DO228138	PBCA	ICGC	PTPSTT	DEG_SCF_FBW7_1	10:15	Mutation altering degron motif	0.7069
p.S13N	DO228138	PBCA	ICGC	PSTTS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7069
p.P12L	DO228159	PBCA	ICGC	PTPSTT	DEG_SCF_FBW7_1	10:15	Mutation altering degron motif	0.7582
p.P12L	DO228159	PBCA	ICGC	PSTTS	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7582
p.G1224R	DO37474	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	1213:1217	Mutation rewiring degron network	0.1389
p.E704D	DO48009	STAD	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1944
p.A1211T	DO38332	STAD	ICGC	PHSSS	DEG_SPOP_SBC_1	1213:1217	Mutation rewiring degron network	0.2778
p.E704K	DO41235	UCEC	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.1944
p.H700R	SIDM00506	Small Cell Lung Carcinoma	GDSC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.0833
p.H700R	COR-L88	lung	COSMIC	LSNTPHAS	DEG_SCF_FBW7_1	709:716	Mutation rewiring degron network	0.0833
p.P1073L	ACH-000841	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.P1073L	ACH-002368	Non-Cancerous	CCLE	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.1667
p.H1092R	ACH-000896	Bladder Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833
p.H1092R	647-V	urinary tract	COSMIC	PHSSS	DEG_SPOP_SBC_1	1079:1083	Mutation rewiring degron network	0.0833

Kaplan plot for SSH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SSH2

UniProt ID: Q76I76

Entrez ID: 85464

Protein name: Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SSH2 in