DegronMD

Uniprot ID: Q76I76

Source protein: Protein phosphatase Slingshot homolog 2

Source gene: SSH2

Class: DEG_SCF_FBW7_1

Location: 10:15

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 86.7667

COIL: 0.9693

CONS_SCORE: 0.3467

DSS_SCORE: 0.6352

HELIX: 0.0117

FCONS_SCORE: 1.0555

RIG_SCORE: 0.5735

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D24E	DO229026	LICA	ICGC	PTPSTT	DEG_SCF_FBW7_1	0.0833
p.S13N	DO228138	PBCA	ICGC	PTPSTT	DEG_SCF_FBW7_1	0.7069
p.P12L	DO228159	PBCA	ICGC	PTPSTT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SCF_FBW7_1	10:15	PTPSTT	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons