DegronMD

Uniprot ID: Q76I76

Source protein: Protein phosphatase Slingshot homolog 2

Source gene: SSH2

Class: DEG_SCF_FBW7_1

Location: 709:716

E3 ligase: FBXW7

DEGRON score: 0.988

ASA_SCORE: 95.275

COIL: 0.878

CONS_SCORE: 0.3609

DSS_SCORE: 0.7368

HELIX: 0.1033

FCONS_SCORE: 1.459

RIG_SCORE: 0.5749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S706I	TCGA-B5-A1MR	UCEC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	0.6944
p.E724G	TCGA-D1-A163	UCEC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	0.1111
p.M721I	TCGA-EA-A410	CESC	TCGA	LSNTPHAS	DEG_SCF_FBW7_1	0.1944
p.R715Q	DO48566	BLCA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.7329
p.G708E	DO225334	BRCA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.3056
p.A722S	DO228815	LICA	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.1667
p.M703I	DO32516	OV	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.1667
p.M703I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	LSNTPHAS	DEG_SCF_FBW7_1	0.1667
p.M703I	KYSE-50	oesophagus	COSMIC	LSNTPHAS	DEG_SCF_FBW7_1	0.1667
p.E704D	DO48009	STAD	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.1944
p.E704K	DO41235	UCEC	ICGC	LSNTPHAS	DEG_SCF_FBW7_1	0.1944
p.H700R	SIDM00506	Small Cell Lung Carcinoma	GDSC	LSNTPHAS	DEG_SCF_FBW7_1	0.0833
p.H700R	COR-L88	lung	COSMIC	LSNTPHAS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SCF_FBW7_1	709:716	LSNTPHAS	FBXW7	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons