DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 185:189

E3 ligase: SPOP

DEGRON score: 0.97

ASA_SCORE: 64.58

COIL: 0.852

CONS_SCORE: 0.6397

DSS_SCORE: 0.749

HELIX: 0.0684

FCONS_SCORE: 1.0683

RIG_SCORE: 0.5627

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V198L	TCGA-05-4417	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.0833
p.V198L	DO23570	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0833
p.D197Y	TCGA-17-Z031	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1111
p.G183V	TCGA-21-5786	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183V	DO26830	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G193V	TCGA-55-7994	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2222
p.G193V	DO45311	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2222
p.L180H	TCGA-66-2759	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L180H	TCGA-VQ-A8PH	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L180H	DO27326	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L180H	DO222349	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.S182R	TCGA-92-7340	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.25
p.S182R	DO26775	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.G183R	TCGA-98-A53A	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183R	TCGA-CS-5395	LGG	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183R	DO22356	LGG	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183R	DO219178	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183R	SIDM00879	Breast Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.G183R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.E175K	TCGA-A5-A2K5	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E175K	DO41379	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.S191A	TCGA-D5-6924	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.2778
p.S191A	DO7922	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.L180P	TCGA-DD-A3A9	LIHC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L180P	DO44888	LIHC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.S186L	TCGA-EO-A3AY	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.6556
p.S186L	TCGA-F5-6863	READ	TCGA	ASSTS	DEG_SPOP_SBC_1	0.6556
p.S186L	DO37042	READ	ICGC	ASSTS	DEG_SPOP_SBC_1	0.6556
p.S186L	DO43202	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.6556
p.A199S	DO223069	ESCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.S182G	DO231007	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.K176N	DO229083	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.V198M	SIDM01300	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.0833
p.S181C	SIDM00541	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.2222
p.S181C	ACH-000926	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.2222
p.S181C	HT55	large_intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.2222
p.R177K	SIDM00545	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177K	ACH-000987	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177K	Mewo	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.S191T	SIDM00545	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.S191T	ACH-000987	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.2778
p.S191T	Mewo	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.2778
p.E175D	SIDM00967	Ovarian Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E175D	ACH-002181	Ovarian Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E175D	OVCA420	ovary	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.R177S	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177S	ACH-000451	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177S	ACH-000921	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.1111
p.R177S	NCI-H2085	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1446:1450	ASSTS	SPOP	0.9991	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	578:582	ASSTS	SPOP	0.9737	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1755:1759	ASSTS	SPOP	0.6619	More...
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	630:634	ASSTS	SPOP	0.9397	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	85:89	ASSTS	SPOP	0.9434	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1352:1356	ASSTS	SPOP	0.9983	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	148:152	ASSTS	SPOP	0.9958	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	2:6	ASSTS	SPOP	0.9282	More...
Q04724	Transducin-like enhancer protein 1	DEG_SPOP_SBC_1	294:298	ASSTS	SPOP	0.9961	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	180:184	ASSTS	SPOP	0.9864	More...
Q5T5U3	Rho GTPase-activating protein 21	DEG_SPOP_SBC_1	791:795	ASSTS	SPOP	0.9947	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	520:524	ASSTS	SPOP	0.8668	More...
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SPOP_SBC_1	723:727	ASSTS	SPOP	0.9991	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1125:1129	ASSTS	SPOP	0.9989	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	255:259	ASSTS	SPOP	0.9466	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6830:6834	ASSTS	SPOP	0.963	More...
Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	DEG_SPOP_SBC_1	14:18	ASSTS	SPOP	0.9523	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	452:456	ASSTS	SPOP	0.9768	More...
Q8N8S7	Protein enabled homolog	DEG_SPOP_SBC_1	484:488	ASSTS	SPOP	0.9828	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	676:680	ASSTS	SPOP	0.9986	More...
Q96JM7	Lethal	DEG_SPOP_SBC_1	5:9	ASSTS	SPOP	0.9955	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	98:102	ASSTS	SPOP	0.9954	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	185:189	ASSTS	SPOP	0.97	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	525:529	ASSTS	SPOP	0.908	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1176:1180	ASSTS	SPOP	0.9955	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	158:162	ASSTS	SPOP	0.9526	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	227:231	ASSTS	SPOP	0.9062	More...
Q5RHP9	Glutamate-rich protein 3	DEG_SPOP_SBC_1	580:584	ASSTS	SPOP	0.9566	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SPOP_SBC_1	23:27	ASSTS	SPOP	0.5181	More...
Q92628	Uncharacterized protein KIAA0232	DEG_SPOP_SBC_1	1366:1370	ASSTS	SPOP	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTS

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of ASSTS