DegronMD - Q04724(TLE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K316N	TCGA-28-1745	GBM	TCGA	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation substituting flanking lysine	0.1667
p.K316N	DO13977	GBM	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation substituting flanking lysine	0.1667
p.T290M	TCGA-A5-A0G1	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.6667
p.T290M	DO42472	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.6667
p.R323W	TCGA-A5-A2K3	UCEC	TCGA	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.25
p.R323W	DO43899	UCEC	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.25
p.A333T	TCGA-A6-2686	COAD	TCGA	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.3056
p.A333T	DO7828	COAD	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.3056
p.E303G	TCGA-BR-8589	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.E303G	DO47813	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.H132R	TCGA-DI-A1BU	UCEC	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	141:148	Mutation rewiring degron network	0.0833
p.H132R	DO42023	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	141:148	Mutation rewiring degron network	0.0833
p.S285T	TCGA-E7-A541	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.5278
p.S285T	DO44037	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.5278
p.E303D	TCGA-EY-A1GI	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.E303D	DO41211	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.P287A	TCGA-FD-A3B6	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.P287A	DO458	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.A291T	TCGA-GV-A3QI	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A291T	DO470	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.S296F	TCGA-QQ-A5VD	SARC	TCGA	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7982
p.S296F	DO220252	SARC	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7982
p.P143T	DO219018	BLCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	141:148	Mutation altering degron motif	0.7031
p.S324T	DO225106	BRCA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.2778
p.R338L	DO234401	ESAD	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667
p.P329Q	DO229024	LICA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7035
p.T328K	DO229032	LICA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7306
p.G138R	DO229054	LICA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	141:148	Mutation rewiring degron network	0.25
p.M304I	DO228489	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.S296Y	DO229539	UTCA	ICGC	ASSTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.712
p.T328M	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.T328M	SIDM00813	Non-Cancerous	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.T328M	SIDM00905	Cervical Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.T328M	SIDM00898	Breast Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.T328M	SIDM00752	Non-Cancerous	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.T328M	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation altering degron motif	0.7423
p.R338C	SIDM00686	Endometrial Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667
p.R338C	ACH-000293	Endometrial/Uterine Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667
p.R338C	KLE	endometrium	COSMIC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667
p.P142S	SIDM00887	Other Solid Cancers	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	141:148	Mutation altering degron motif	0.5641
p.T321M	SIDM00814	Other Solid Cancers	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1944
p.T321M	ACH-001401	Adrenal Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1944
p.T321M	SW13	adrenal gland	COSMIC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1944
p.P320S	SIDM01387	Small Cell Lung Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667
p.P320S	ACH-000921	Lung Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	326:332	Mutation rewiring degron network	0.1667

Kaplan plot for TLE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLE1

UniProt ID: Q04724

Entrez ID: 7088

Protein name: Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLE1 in