DegronMD

Uniprot ID: Q04724

Source protein: Transducin-like enhancer protein 1

Source gene: TLE1

Class: DEG_SCF_FBW7_1

Location: 141:148

E3 ligase: FBXW7

DEGRON score: 0.9677

ASA_SCORE: 72.8

COIL: 0.9396

CONS_SCORE: 0.452

DSS_SCORE: 0.7737

HELIX: 0.0154

FCONS_SCORE: 1.0201

RIG_SCORE: 0.5703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H132R	TCGA-DI-A1BU	UCEC	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.0833
p.H132R	DO42023	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.0833
p.P143T	DO219018	BLCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7031
p.G138R	DO229054	LICA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.25
p.P142S	SIDM00887	Other Solid Cancers	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04724	Transducin-like enhancer protein 1	DEG_SCF_FBW7_1	141:148	VPLTPHPS	FBXW7	0.9677	More...
Q04727	Transducin-like enhancer protein 4	DEG_SCF_FBW7_1	146:153	VPLTPHPS	FBXW7	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons