DegronMD - Q04727(TLE4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P290L	TCGA-4Z-AA89	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.P290L	TCGA-D1-A17Q	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.P290L	TCGA-F7-A50I	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.A159G	TCGA-AA-3511	COAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.1667
p.P158L	TCGA-AA-3715	COAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.1944
p.A289G	TCGA-AA-3977	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.L144R	TCGA-BF-A3DL	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.2778
p.S295C	TCGA-D3-A1Q3	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.7222
p.P145L	TCGA-D3-A2J8	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.3056
p.P145L	TCGA-FS-A1ZM	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.3056
p.P293L	TCGA-FW-A3R5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2222
p.H142N	TCGA-G3-A7M9	LIHC	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.2222
p.L148V	TCGA-K4-A54R	BLCA	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.5654
p.H151Q	TCGA-MP-A4TF	LUAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.647
p.E309Q	TCGA-VS-A8EL	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.R304L	DO223588	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.V295F	DO2783	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.7222
p.L287F	DO51224	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation substituting flanking lysine	0.1667
p.S140G	DO218491	BTCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.1667
p.D306N	DO44377	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation substituting flanking lysine	0.3056
p.G143R	DO8490	COAD	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.25
p.Q154H	DO52483	COCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.3056
p.S148F	DO15623	HNSC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.7982
p.K297N	DO23258	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6918
p.P136S	DO220895	MELA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.0556
p.L151P	DO222619	MELA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.7582
p.L151P	DO38075	SKCM	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.7582
p.A146S	DO34640	PACA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.7588
p.R304Q	DO228599	PRAD	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.R304Q	DO47700	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.R304Q	DO49073	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P310T	DO37679	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0833
p.S149T	DO38623	STAD	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.7116
p.A146V	DO42280	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.6936
p.Q154K	DO42472	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.3056
p.P150S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.6752
p.P150S	ACH-000627	Lung Cancer	CCLE	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.6752
p.P150S	LCLC-103H	lung	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.6752
p.V146I	SIDM00217	Colorectal Carcinoma	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.5965
p.V146I	ACH-000999	Colon/Colorectal Cancer	CCLE	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.5965
p.V146I	SNU-1040	large intestine	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation altering degron motif	0.5965
p.S301T	SIDM01018	Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005
p.S301T	ACH-000815	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005
p.S301T	KM-H2	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.6005
p.S290R	CW-2	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1389
p.S140N	KYSE-450	oesophagus	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.1667
p.P158S	CHSA8926	bone	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	146:153	Mutation rewiring degron network	0.1944
p.T302A	H2869	pleura	COSMIC	ASSSS	DEG_SPOP_SBC_1	297:301	Mutation blocking phosphorylation signal	0.75

Kaplan plot for TLE4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLE4

UniProt ID: Q04727

Entrez ID: 7091

Protein name: Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLE4 in