DegronMD

Uniprot ID: Q04727

Source protein: Transducin-like enhancer protein 4

Source gene: TLE4

Class: DEG_SCF_FBW7_1

Location: 146:153

E3 ligase: FBXW7

DEGRON score: 0.9947

ASA_SCORE: 62.375

COIL: 0.949

CONS_SCORE: 0.3804

DSS_SCORE: 0.6291

HELIX: 0.0179

FCONS_SCORE: 0.8804

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A159G	TCGA-AA-3511	COAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.1667
p.P158L	TCGA-AA-3715	COAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.1944
p.L144R	TCGA-BF-A3DL	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.2778
p.P145L	TCGA-D3-A2J8	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.3056
p.P145L	TCGA-FS-A1ZM	SKCM	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.3056
p.H142N	TCGA-G3-A7M9	LIHC	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.2222
p.L148V	TCGA-K4-A54R	BLCA	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.5654
p.H151Q	TCGA-MP-A4TF	LUAD	TCGA	VPLTPHPS	DEG_SCF_FBW7_1	0.647
p.S140G	DO218491	BTCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.1667
p.G143R	DO8490	COAD	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.25
p.Q154H	DO52483	COCA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.3056
p.S148F	DO15623	HNSC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7982
p.P136S	DO220895	MELA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.0556
p.L151P	DO222619	MELA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7582
p.L151P	DO38075	SKCM	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7582
p.A146S	DO34640	PACA	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7588
p.S149T	DO38623	STAD	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.7116
p.A146V	DO42280	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.6936
p.Q154K	DO42472	UCEC	ICGC	VPLTPHPS	DEG_SCF_FBW7_1	0.3056
p.P150S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	0.6752
p.P150S	ACH-000627	Lung Cancer	CCLE	VPLTPHPS	DEG_SCF_FBW7_1	0.6752
p.P150S	LCLC-103H	lung	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	0.6752
p.V146I	SIDM00217	Colorectal Carcinoma	GDSC	VPLTPHPS	DEG_SCF_FBW7_1	0.5965
p.V146I	ACH-000999	Colon/Colorectal Cancer	CCLE	VPLTPHPS	DEG_SCF_FBW7_1	0.5965
p.V146I	SNU-1040	large_intestine	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	0.5965
p.S140N	KYSE-450	oesophagus	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	0.1667
p.P158S	CHSA8926	bone	COSMIC	VPLTPHPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04724	Transducin-like enhancer protein 1	DEG_SCF_FBW7_1	141:148	VPLTPHPS	FBXW7	0.9677	More...
Q04727	Transducin-like enhancer protein 4	DEG_SCF_FBW7_1	146:153	VPLTPHPS	FBXW7	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPLTPHPS

Degron related mutations and impact score

Drug responses associated with TLE4 mutations

All proteins holding degron of VPLTPHPS