DegronMD

Uniprot ID: Q04724

Source protein: Transducin-like enhancer protein 1

Source gene: TLE1

Class: DEG_SCF_FBW7_1

Location: 326:332

E3 ligase: FBXW7

DEGRON score: 0.9772

ASA_SCORE: 75

COIL: 0.9394

CONS_SCORE: 0.3928

DSS_SCORE: 0.7944

HELIX: 0.0256

FCONS_SCORE: 0.9091

RIG_SCORE: 0.5612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K316N	TCGA-28-1745	GBM	TCGA	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.K316N	DO13977	GBM	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.R323W	TCGA-A5-A2K3	UCEC	TCGA	MPTPGTS	DEG_SCF_FBW7_1	0.25
p.R323W	DO43899	UCEC	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.25
p.A333T	TCGA-A6-2686	COAD	TCGA	MPTPGTS	DEG_SCF_FBW7_1	0.3056
p.A333T	DO7828	COAD	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.3056
p.S324T	DO225106	BRCA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.2778
p.R338L	DO234401	ESAD	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.P329Q	DO229024	LICA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.7035
p.T328K	DO229032	LICA	ICGC	MPTPGTS	DEG_SCF_FBW7_1	0.7306
p.T328M	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.T328M	SIDM00813	Non-Cancerous	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.T328M	SIDM00905	Cervical Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.T328M	SIDM00898	Breast Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.T328M	SIDM00752	Non-Cancerous	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.T328M	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.7423
p.R338C	SIDM00686	Endometrial Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.R338C	ACH-000293	Endometrial/Uterine Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.R338C	KLE	endometrium	COSMIC	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.T321M	SIDM00814	Other Solid Cancers	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.1944
p.T321M	ACH-001401	Adrenal Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	0.1944
p.T321M	SW13	adrenal_gland	COSMIC	MPTPGTS	DEG_SCF_FBW7_1	0.1944
p.P320S	SIDM01387	Small Cell Lung Carcinoma	GDSC	MPTPGTS	DEG_SCF_FBW7_1	0.1667
p.P320S	ACH-000921	Lung Cancer	CCLE	MPTPGTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04724	Transducin-like enhancer protein 1	DEG_SCF_FBW7_1	326:332	MPTPGTS	FBXW7	0.9772	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons