DegronMD

Uniprot ID: Q96JM7

Source protein: Lethal

Source gene: L3MBTL3

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 77.54

COIL: 0.8906

CONS_SCORE: 0.4897

DSS_SCORE: 0.6254

HELIX: 0.0902

FCONS_SCORE: 1.1425

RIG_SCORE: 0.6429

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D14E	TCGA-18-3414	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1944
p.D14E	DO26629	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.G10C	TCGA-D3-A1QA	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	0.3056
p.G10C	DO47469	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	0.3056
p.S4Y	TCGA-JW-A5VL	CESC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.3056
p.S4Y	DO49976	CESC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.3056
p.E12K	TCGA-TN-A7HJ	HNSC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.25
p.E12K	DO219077	HNSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.S6F	DO225354	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.7982
p.F13L	SIDM00850	Gastric Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.2222
p.F13L	ACH-000880	Gastric Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.2222
p.F13L	AGS	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.2222

Drug responses associated with L3MBTL3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R210W (No)	GDSC	UNC1215	6.7012
SIDM00315	GBM\|glioma	p.S256P (No)	GDSC	UNC1215	11.8707
SIDM00966	OV\|ovary	p.V286I (No)	GDSC	UNC1215	8.4214
SIDM00348	ESCA\|oesophagus	p.L600V (No)	GDSC	UNC1215	10.0945
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.A287T (No)	GDSC	UNC1215	6.1158
SIDM00550	ESCA\|oesophagus	p.S134F (No)	GDSC	UNC1215	10.1563
SIDM01174	CESC\|cervix	p.G737E (No)	GDSC	UNC1215	17.8715
SIDM00341	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y301C (No)	GDSC	UNC1215	14.1371
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R145W (No)	GDSC	UNC1215	3.5252
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.N54S (No)	GDSC	UNC1215	7.131
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.S579C (No)	GDSC	UNC1215	32.5494
SIDM00411	PAAD\|pancreas	p.K101R (No)	GDSC	UNC1215	21.8633
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712G (No)	GDSC	UNC1215	23.4909
SIDM00117	LUAD\|lung_NSCLC_adenocarcinoma	p.E712D (No)	GDSC	UNC1215	23.4909
SIDM00598	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R145W (No)	GDSC	UNC1215	14.685
SIDM00425	OV\|ovary	p.R145W (No)	GDSC	UNC1215	17.3986
SIDM00217	COREAD\|large_intestine	p.R210L (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R372Q (No)	GDSC	UNC1215	11.3851
SIDM00217	COREAD\|large_intestine	p.R599C (No)	GDSC	UNC1215	11.3851
SIDM00082	SKCM\|melanoma	p.E53G (No)	GDSC	UNC1215	39.4978
SIDM00889	CESC\|cervix	p.G136R (No)	GDSC	UNC1215	9.7675
SIDM00660	COREAD\|large_intestine	p.R210W (No)	GDSC	UNC1215	15.1239
SIDM01245	ALL\|lymphoblastic_leukemia	p.A58S (No)	GDSC	UNC1215	5.1078
SIDM01189	GBM\|glioma	p.I388F (No)	GDSC	UNC1215	28.0837
SIDM01242	SKCM\|melanoma	p.R145W (No)	GDSC	UNC1215	19.5414
SIDM00789	COREAD\|large_intestine	p.P81S (No)	GDSC	UNC1215	14.2422
SIDM00789	COREAD\|large_intestine	p.W415R (No)	GDSC	UNC1215	14.2422
SIDM00534	COREAD\|large_intestine	p.S524Y (No)	GDSC	UNC1215	12.3123
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.L346H (No)	GDSC	UNC1215	7.228
SIDM01033	BLCA\|bladder	p.R145W (No)	GDSC	UNC1215	9.5862
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S601I (No)	GDSC	UNC1215	14.8032
SIDM01110	LIHC\|liver	p.T746A (No)	GDSC	UNC1215	9.0866
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F298L (No)	GDSC	UNC1215	14.7152
SIDM00549	ALL\|lymphoblastic_leukemia	p.P461S (No)	GDSC	UNC1215	13.2877
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.I364T (No)	GDSC	UNC1215	16.4385
SIDM01259	ALL\|lymphoblastic_leukemia	p.P525L (No)	GDSC	UNC1215	17.2582
SIDM01040	OV\|ovary	p.R145W (No)	GDSC	UNC1215	16.2436
SIDM00659	GBM\|glioma	p.R171Q (No)	GDSC	UNC1215	13.1123
SIDM01104	SKCM\|melanoma	p.T644P (No)	GDSC	UNC1215	17.0795
SIDM00481	OV\|ovary	p.E338K (No)	GDSC	UNC1215	19.1246
SIDM00562	BRCA\|breast	p.C304F (No)	GDSC	UNC1215	14.7113
SIDM00332	BRCA\|breast	p.Q352E (No)	GDSC	UNC1215	28.1858

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1446:1450	ASSTS	SPOP	0.9991	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	578:582	ASSTS	SPOP	0.9737	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1755:1759	ASSTS	SPOP	0.6619	More...
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	630:634	ASSTS	SPOP	0.9397	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	85:89	ASSTS	SPOP	0.9434	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1352:1356	ASSTS	SPOP	0.9983	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	148:152	ASSTS	SPOP	0.9958	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	2:6	ASSTS	SPOP	0.9282	More...
Q04724	Transducin-like enhancer protein 1	DEG_SPOP_SBC_1	294:298	ASSTS	SPOP	0.9961	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	180:184	ASSTS	SPOP	0.9864	More...
Q5T5U3	Rho GTPase-activating protein 21	DEG_SPOP_SBC_1	791:795	ASSTS	SPOP	0.9947	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	520:524	ASSTS	SPOP	0.8668	More...
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SPOP_SBC_1	723:727	ASSTS	SPOP	0.9991	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1125:1129	ASSTS	SPOP	0.9989	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	255:259	ASSTS	SPOP	0.9466	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6830:6834	ASSTS	SPOP	0.963	More...
Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	DEG_SPOP_SBC_1	14:18	ASSTS	SPOP	0.9523	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	452:456	ASSTS	SPOP	0.9768	More...
Q8N8S7	Protein enabled homolog	DEG_SPOP_SBC_1	484:488	ASSTS	SPOP	0.9828	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	676:680	ASSTS	SPOP	0.9986	More...
Q96JM7	Lethal	DEG_SPOP_SBC_1	5:9	ASSTS	SPOP	0.9955	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	98:102	ASSTS	SPOP	0.9954	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	185:189	ASSTS	SPOP	0.97	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	525:529	ASSTS	SPOP	0.908	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1176:1180	ASSTS	SPOP	0.9955	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	158:162	ASSTS	SPOP	0.9526	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	227:231	ASSTS	SPOP	0.9062	More...
Q5RHP9	Glutamate-rich protein 3	DEG_SPOP_SBC_1	580:584	ASSTS	SPOP	0.9566	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SPOP_SBC_1	23:27	ASSTS	SPOP	0.5181	More...
Q92628	Uncharacterized protein KIAA0232	DEG_SPOP_SBC_1	1366:1370	ASSTS	SPOP	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTS

Degron related mutations and impact score

Drug responses associated with L3MBTL3 mutations

All proteins holding degron of ASSTS