DegronMD - Q6ZUJ8(PIK3AP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G146V	TCGA-12-1088	GBM	TCGA	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation altering degron motif	0.7532
p.G146V	DO13701	GBM	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation altering degron motif	0.7532
p.P777T	TCGA-18-3406	LUSC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.1944
p.G741R	TCGA-2W-A8YY	CESC	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation rewiring degron network	0.2222
p.E753D	TCGA-A5-A0G1	UCEC	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation altering degron motif	0.5647
p.V134M	TCGA-AP-A051	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0556
p.V134M	DO42673	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0556
p.A140T	TCGA-AZ-4315	COAD	TCGA	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.2222
p.A140T	TCGA-FI-A2D5	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.2222
p.A140T	DO8842	COAD	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.2222
p.A140T	DO41331	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.2222
p.A136T	TCGA-B5-A3FA	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1111
p.A136T	DO52402	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1111
p.S718I	TCGA-B5-A3FC	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation blocking phosphorylation signal	0.6389
p.E774Q	TCGA-BA-5152	HNSC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.2778
p.P763T	TCGA-D3-A2JP	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation rewiring degron network	0.0833
p.P763T	TCGA-D3-A2JP	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.2778
p.P752H	TCGA-D3-A2JP	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation altering degron motif	0.7694
p.R758C	TCGA-DA-A95Z	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation rewiring degron network	0.2222
p.R758C	TCGA-DA-A95Z	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.1389
p.R758H	TCGA-DF-A2KN	UCEC	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation rewiring degron network	0.2222
p.R758H	TCGA-DF-A2KN	UCEC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.1389
p.S772F	TCGA-EE-A181	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation altering degron motif	0.7982
p.V754G	TCGA-FR-A3YN	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	745:754	Mutation altering degron motif	0.7532
p.S724N	TCGA-FW-A3R5	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.5958
p.T770I	TCGA-XK-AAIW	PRAD	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation altering degron motif	0.5966
p.E147Q	DO3095	BRCA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation altering degron motif	0.6744
p.H137N	DO229038	LICA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1389
p.F139V	DO23112	LINC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation substituting flanking lysine	0.3056
p.E158V	DO230931	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0833
p.E158V	DO224548	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0833
p.D155Y	DO219157	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1667
p.S142F	DO222420	MELA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.2778
p.G135E	DO219478	SKCM	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0833
p.D148Y	DO43202	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	144:149	Mutation altering degron motif	0.6214
p.P781S	SIDM00545	Melanoma	GDSC	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.0833
p.P781S	ACH-000987	Skin Cancer	CCLE	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.0833
p.P781S	Mewo	skin	COSMIC	VDGTPTMS	DEG_SCF_FBW7_1	765:772	Mutation rewiring degron network	0.0833
p.R733W	SIDM01483	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1667
p.R733W	ACH-000582	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1667
p.R733W	COLO-741	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1667
p.S724R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.6316
p.S724R	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.6316
p.T726I	SIDM00793	Burkitt's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7078
p.T726I	ACH-002236	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7078
p.T726I	EB-3	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7078
p.A723T	SIDM00217	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7139
p.A723T	ACH-000999	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7139
p.A723T	SNU-1040	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7139
p.T732I	SIDM00808	Burkitt's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T732I	SIDM01254	Burkitt's Lymphoma	GDSC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T732I	ACH-000707	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T732I	ACH-002252	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T732I	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T722I	ACH-001522	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.3056

Kaplan plot for PIK3AP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIK3AP1

UniProt ID: Q6ZUJ8

Entrez ID: 118788

Protein name: Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIK3AP1 in