DegronMD

Uniprot ID: Q6ZUJ8

Source protein: Phosphoinositide 3-kinase adapter protein 1

Source gene: PIK3AP1

Class: DEG_COP1_1

Location: 745:754

E3 ligase: COP1

DEGRON score: 0.9991

ASA_SCORE: 96.99

COIL: 0.8408

CONS_SCORE: 0.4119

DSS_SCORE: 0.7772

HELIX: 0.1498

FCONS_SCORE: 1.0499

RIG_SCORE: 0.6246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G741R	TCGA-2W-A8YY	CESC	TCGA	DNEDNEVPEV	DEG_COP1_1	0.2222
p.E753D	TCGA-A5-A0G1	UCEC	TCGA	DNEDNEVPEV	DEG_COP1_1	0.5647
p.P763T	TCGA-D3-A2JP	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	0.0833
p.P752H	TCGA-D3-A2JP	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	0.7694
p.R758C	TCGA-DA-A95Z	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	0.2222
p.R758H	TCGA-DF-A2KN	UCEC	TCGA	DNEDNEVPEV	DEG_COP1_1	0.2222
p.V754G	TCGA-FR-A3YN	SKCM	TCGA	DNEDNEVPEV	DEG_COP1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_COP1_1	745:754	DNEDNEVPEV	COP1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons