DegronMD

Uniprot ID: Q6ZUJ8

Source protein: Phosphoinositide 3-kinase adapter protein 1

Source gene: PIK3AP1

Class: DEG_SCF_FBW7_1

Location: 765:772

E3 ligase: FBXW7

DEGRON score: 0.9328

ASA_SCORE: 86.9

COIL: 0.9364

CONS_SCORE: 0.3584

DSS_SCORE: 0.8529

HELIX: 0.0405

FCONS_SCORE: 0.8671

RIG_SCORE: 0.5751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P777T	TCGA-18-3406	LUSC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.1944
p.E774Q	TCGA-BA-5152	HNSC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.2778
p.P763T	TCGA-D3-A2JP	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.2778
p.R758C	TCGA-DA-A95Z	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.1389
p.R758H	TCGA-DF-A2KN	UCEC	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.1389
p.S772F	TCGA-EE-A181	SKCM	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.7982
p.T770I	TCGA-XK-AAIW	PRAD	TCGA	VDGTPTMS	DEG_SCF_FBW7_1	0.5966
p.P781S	SIDM00545	Melanoma	GDSC	VDGTPTMS	DEG_SCF_FBW7_1	0.0833
p.P781S	ACH-000987	Skin Cancer	CCLE	VDGTPTMS	DEG_SCF_FBW7_1	0.0833
p.P781S	Mewo	skin	COSMIC	VDGTPTMS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SCF_FBW7_1	765:772	VDGTPTMS	FBXW7	0.9328	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons