DegronMD

Uniprot ID: Q6ZUJ8

Source protein: Phosphoinositide 3-kinase adapter protein 1

Source gene: PIK3AP1

Class: DEG_SCF_TRCP1_1

Location: 144:149

E3 ligase: BTRC

DEGRON score: 0.903

ASA_SCORE: 57.2833

COIL: 0.7553

CONS_SCORE: 0.3176

DSS_SCORE: 0.5351

HELIX: 0.1858

FCONS_SCORE: 0.9668

RIG_SCORE: 0.6669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G146V	TCGA-12-1088	GBM	TCGA	DSGCDS	DEG_SCF_TRCP1_1	0.7532
p.G146V	DO13701	GBM	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.7532
p.V134M	TCGA-AP-A051	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	0.0556
p.V134M	DO42673	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.0556
p.A140T	TCGA-AZ-4315	COAD	TCGA	DSGCDS	DEG_SCF_TRCP1_1	0.2222
p.A140T	TCGA-FI-A2D5	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	0.2222
p.A140T	DO8842	COAD	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.2222
p.A140T	DO41331	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.2222
p.A136T	TCGA-B5-A3FA	UCEC	TCGA	DSGCDS	DEG_SCF_TRCP1_1	0.1111
p.A136T	DO52402	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.1111
p.E147Q	DO3095	BRCA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.6744
p.H137N	DO229038	LICA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.1389
p.F139V	DO23112	LINC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.3056
p.E158V	DO230931	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.0833
p.E158V	DO224548	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.0833
p.D155Y	DO219157	LUSC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.1667
p.S142F	DO222420	MELA	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.2778
p.G135E	DO219478	SKCM	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.0833
p.D148Y	DO43202	UCEC	ICGC	DSGCDS	DEG_SCF_TRCP1_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SCF_TRCP1_1	144:149	DSGCDS	BTRC	0.903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons