DegronMD - Q5T5U3(ARHGAP21)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T980R	TCGA-06-0154	GBM	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation blocking phosphorylation signal	0.6389
p.T980R	DO12292	GBM	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation blocking phosphorylation signal	0.6389
p.G1087C	TCGA-09-2044	OV	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.0833
p.G1087C	DO28923	OV	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.0833
p.P796Q	TCGA-13-0760	OV	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.3056
p.P796Q	DO28541	OV	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.3056
p.V781L	TCGA-13-1481	OV	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.V781L	DO31789	OV	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.N1062K	TCGA-13-1509	OV	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.0833
p.N1062K	DO30740	OV	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.0833
p.G885S	TCGA-19-1385	GBM	TCGA	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.25
p.G885S	DO13761	GBM	ICGC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.25
p.Q1555R	TCGA-21-1077	LUSC	TCGA	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation rewiring degron network	0.2222
p.Q1555R	DO26725	LUSC	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation rewiring degron network	0.2222
p.M786I	TCGA-37-3792	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.M786I	DO27192	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.M961I	TCGA-44-6775	LUAD	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.M961I	DO24517	LUAD	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.R1467K	TCGA-56-8625	LUSC	TCGA	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1389
p.R1467K	DO45515	LUSC	ICGC	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1389
p.H968R	TCGA-66-2769	LUSC	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2778
p.H968R	DO26522	LUSC	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2778
p.M99V	TCGA-86-8056	LUAD	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6097
p.M99V	DO24950	LUAD	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6097
p.D1482H	TCGA-A8-A0A9	BRCA	TCGA	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.2222
p.D1482H	DO2473	BRCA	ICGC	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.2222
p.R1076C	TCGA-AA-A02R	COAD	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.719
p.S625Y	TCGA-AJ-A3EK	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.S625Y	TCGA-AX-A05Z	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.S625Y	TCGA-EY-A1GI	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.S625Y	DO40884	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.S625Y	DO41584	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.S625Y	DO41211	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation blocking phosphorylation signal	0.6944
p.R789I	TCGA-AN-A046	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.R789I	DO1285	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.2778
p.V781F	TCGA-AR-A0TT	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.V781F	DO2246	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.R95H	TCGA-AX-A1CE	UCEC	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7133
p.R95H	DO42280	UCEC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7133
p.R95H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7133
p.R95H	ACH-002059	Leukemia	CCLE	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7133
p.R95H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.7133
p.F1442V	TCGA-B5-A11N	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.3056
p.F1442V	DO41458	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.3056
p.K1443N	TCGA-B5-A1MX	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation altering degron motif	0.5806
p.K1443N	DO41999	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation altering degron motif	0.5806
p.R966L	TCGA-B5-A1MX	UCEC	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.R966L	DO41999	UCEC	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.R966L	SIDM00660	Colorectal Carcinoma	GDSC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.R966L	ACH-000985	Colon/Colorectal Cancer	CCLE	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.R966L	LS-411N	large intestine	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.E978K	TCGA-BH-A0HF	BRCA	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.25
p.E978K	DO1749	BRCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.25
p.P836H	TCGA-BH-A203	BRCA	TCGA	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7694
p.P836H	TCGA-EE-A2M6	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7694
p.P836H	DO2156	BRCA	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7694
p.P836H	DO37976	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7694
p.R609Q	TCGA-BR-8361	STAD	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	DO48032	STAD	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00194	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00557	Neuroblastoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00216	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00600	Thyroid Gland Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00281	Other Solid Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00530	Esophageal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00596	Endometrial Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00018	Acute Myeloid Leukemia	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01217	Other Blood Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00543	Melanoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM00302	Other Solid Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01449	Pancreatic Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01570	Ovarian Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01622	Breast Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01368	Gastric Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01432	Kidney Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01435	Hepatocellular Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.R609Q	SIDM01343	Gastric Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1944
p.S800A	TCGA-BS-A0UF	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.S800A	DO41488	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1944
p.R1076H	TCGA-CK-4951	COAD	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	DO10582	COAD	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	SIDM00216	Colorectal Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	SIDM00120	Prostate Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	ACH-000979	Prostate Cancer	CCLE	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	ACH-000989	Colon/Colorectal Cancer	CCLE	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	SNU-175	large intestine	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.R1076H	DU-145	prostate	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.7133
p.H632Y	TCGA-D1-A160	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.0556
p.H632Y	DO41626	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.0556
p.R1076S	TCGA-D3-A2JC	SKCM	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.6316
p.R1076S	DO47578	SKCM	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation altering degron motif	0.6316
p.N1452S	TCGA-DF-A2KN	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1944
p.N1452S	DO223282	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1944
p.N1452S	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1944
p.N1452S	ACH-000438	Lung Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1944
p.N1452S	LU-65	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1944
p.E884K	TCGA-E5-A4TZ	BLCA	TCGA	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.2222
p.E884K	TCGA-SY-A9G5	BLCA	TCGA	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.2222
p.E884K	DO51906	BLCA	ICGC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.2222
p.E884K	DO44055	BLCA	ICGC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.2222
p.P823S	TCGA-EE-A181	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1667
p.P823S	DO37444	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1667
p.P843T	TCGA-EE-A2GR	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.P843T	DO37996	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.P805L	TCGA-EE-A2MS	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.P805L	DO37567	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.0556
p.S1544Y	TCGA-EE-A3AD	SKCM	TCGA	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation rewiring degron network	0.3056
p.S1544Y	DO37707	SKCM	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation rewiring degron network	0.3056
p.R966W	TCGA-EJ-5530	PRAD	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.R966W	DO36264	PRAD	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.N1063S	TCGA-EO-A22R	UCEC	TCGA	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1111
p.N1063S	DO42713	UCEC	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1111
p.R95S	TCGA-ER-A19P	SKCM	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6316
p.R95S	DO47623	SKCM	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6316
p.P982L	TCGA-EY-A2OM	UCEC	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.1389
p.P982L	DO43025	UCEC	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.1389
p.S896F	TCGA-FI-A2D5	UCEC	TCGA	DYR	CBL_MET	888:890	Mutation blocking phosphorylation signal	0.6111
p.I1472V	TCGA-G4-6322	COAD	TCGA	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.2778
p.I1472V	DO8439	COAD	ICGC	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.2778
p.R977T	TCGA-GD-A6C6	BLCA	TCGA	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2778
p.R977T	DO48504	BLCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2778
p.I1471V	TCGA-LN-A49R	ESCA	TCGA	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.25
p.E1436K	TCGA-XF-AAN0	BLCA	TCGA	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1389
p.E1436K	DO51941	BLCA	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.1389
p.S792W	DO225192	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.6763
p.S792L	DO227999	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation altering degron motif	0.6556
p.V963I	DO52481	COCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.1389
p.R622Q	DO52432	COCA	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation altering degron motif	0.6218
p.Q979K	DO228952	LICA	ICGC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.2222
p.C844S	DO228950	LICA	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1667
p.A802D	DO228976	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.1389
p.L1550I	DO229018	LICA	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation altering degron motif	0.6063
p.Q1449K	DO229026	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation rewiring degron network	0.2778
p.M99L	DO23240	LINC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.5999
p.D82G	DO23364	LINC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.0556
p.N1446S	DO34088	PACA	ICGC	KKENV	DEG_APCC_KENBOX_2	1443:1447	Mutation altering degron motif	0.7069
p.S1080I	DO35550	PBCA	ICGC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation blocking phosphorylation signal	0.7222
p.K880R	DO229253	THCA	ICGC	DYR	CBL_MET	888:890	Mutation substituting flanking lysine	0.2222
p.Q834H	DO229229	THCA	ICGC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.647
p.S1484I	SIDM00373	Endometrial Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1667
p.S1484I	ACH-000974	Endometrial/Uterine Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1667
p.Y971C	SIDM01097	Other Solid Cancers	GDSC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.5976
p.Y971C	SK-PN-DW	bone	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.5976
p.I828M	SIDM00049	Colorectal Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.3056
p.I828M	ACH-002233	Colon/Colorectal Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.3056
p.I828M	DIFI	large intestine	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.3056
p.T846K	SIDM00485	Oral Cavity Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1111
p.T846K	ACH-000794	Head and Neck Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1111
p.T846K	BICR22	upper aerodigestive tract	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1111
p.P843H	SIDM00901	Endometrial Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.P843H	ACH-000940	Endometrial/Uterine Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.P843H	AN3-CA	endometrium	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.S1546P	SIDM01463	Endometrial Carcinoma	GDSC	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation altering degron motif	0.6752
p.S1546P	ACH-000397	Endometrial/Uterine Cancer	CCLE	DSGTLLS	DEG_SCF_TRCP1_1	1545:1551	Mutation altering degron motif	0.6752
p.A1068T	SIDM01519	Head and Neck Carcinoma	GDSC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.25
p.V104A	SIDM01574	Plasma Cell Myeloma	GDSC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2222
p.V104A	ACH-000588	Myeloma	CCLE	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2222
p.T1485M	ACH-000937	Leukemia	CCLE	AKENS	DEG_APCC_KENBOX_2	1474:1478	Mutation rewiring degron network	0.1389
p.A830T	ACH-001991	Primary	CCLE	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.6028
p.R843H	VMRC-RCW	kidney	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.R843H	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation rewiring degron network	0.1944
p.Y961C	SK-PN-DW	bone	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.S975N	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.7069
p.S976N	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.3056
p.F796V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	791:795	Mutation rewiring degron network	0.3056
p.T1084I	ML-2	haematopoietic and lymphoid tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1667
p.T836K	BICR22	upper aerodigestive tract	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7306
p.D899Y	SNU-175	large intestine	COSMIC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.0833
p.D1085N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1389
p.N900S	LU-65	lung	COSMIC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.0556
p.S110P	ABC-1	lung	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.0556
p.R1066H	SNU-175	large intestine	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1944
p.R1066H	DU-145	prostate	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1944
p.P630H	AN3-CA	endometrium	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1111
p.A1061V	ES6	bone	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.0556
p.A983P	NCI-H650	lung	COSMIC	LYLYKD	LIG_APCC_ABBA_1	970:975	Mutation blocking phosphorylation signal	0.5556
p.P833H	AN3-CA	endometrium	COSMIC	SASTSQVPSI	DEG_COP1_1	829:838	Mutation altering degron motif	0.7694
p.R94H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.8244
p.E890D	H513	pleura	COSMIC	DYR	CBL_MET	888:890	Mutation altering degron motif	0.6758
p.E87V	MRK-nu-1	breast	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1944
p.T881I	ML-2	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	888:890	Mutation blocking phosphorylation signal	0.5833
p.V623I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.3056
p.D1084N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1667
p.S1065L	QGP-1	pancreas	COSMIC	LPKTPRQS	DEG_SCF_FBW7_1	1071:1078	Mutation rewiring degron network	0.1667
p.R607Q	NCI-H630	large intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1389
p.R608Q	NCI-H630	large intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation rewiring degron network	0.1667
p.I615M	DIFI	large intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	614:622	Mutation altering degron motif	0.7618
p.S891L	PCI-30	upper aerodigestive tract	COSMIC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.3056
p.D900N	KU-19-19	urinary tract	COSMIC	DYR	CBL_MET	888:890	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP21

UniProt ID: Q5T5U3

Entrez ID: 57584

Protein name: Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP21 in