DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_APCC_DBOX_1

Location: 92:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7866

ASA_SCORE: 83.5778

COIL: 0.6954

CONS_SCORE: 0.3449

DSS_SCORE: 0.5535

HELIX: 0.1032

FCONS_SCORE: 1.0326

RIG_SCORE: 0.7425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M99V	TCGA-86-8056	LUAD	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	0.6097
p.M99V	DO24950	LUAD	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	0.6097
p.R95H	TCGA-AX-A1CE	UCEC	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R95H	DO42280	UCEC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R95H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRNRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R95H	ACH-002059	Leukemia	CCLE	QRNRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R95H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	0.7133
p.R95S	TCGA-ER-A19P	SKCM	TCGA	QRNRLEPMD	DEG_APCC_DBOX_1	0.6316
p.R95S	DO47623	SKCM	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	0.6316
p.M99L	DO23240	LINC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	0.5999
p.D82G	DO23364	LINC	ICGC	QRNRLEPMD	DEG_APCC_DBOX_1	0.0556
p.V104A	SIDM01574	Plasma Cell Myeloma	GDSC	QRNRLEPMD	DEG_APCC_DBOX_1	0.2222
p.V104A	ACH-000588	Myeloma	CCLE	QRNRLEPMD	DEG_APCC_DBOX_1	0.2222
p.S110P	ABC-1	lung	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	0.0556
p.R94H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	0.8244
p.E87V	MRK-nu-1	breast	COSMIC	QRNRLEPMD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_DBOX_1	92:100	QRNRLEPMD	APC,CDC20,FZR1	0.7866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons