DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: LIG_APCC_ABBA_1

Location: 970:975

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5903

ASA_SCORE: 36.9167

COIL: 0.2352

CONS_SCORE: 0.3666

DSS_SCORE: 0.316

HELIX: 0.0082

FCONS_SCORE: 1.0433

RIG_SCORE: 0.8417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T980R	TCGA-06-0154	GBM	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.6389
p.T980R	DO12292	GBM	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.6389
p.M961I	TCGA-44-6775	LUAD	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.0833
p.M961I	DO24517	LUAD	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.0833
p.H968R	TCGA-66-2769	LUSC	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.2778
p.H968R	DO26522	LUSC	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.2778
p.R966L	TCGA-B5-A1MX	UCEC	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.R966L	DO41999	UCEC	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.R966L	SIDM00660	Colorectal Carcinoma	GDSC	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.R966L	ACH-000985	Colon/Colorectal Cancer	CCLE	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.R966L	LS-411N	large_intestine	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.E978K	TCGA-BH-A0HF	BRCA	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.25
p.E978K	DO1749	BRCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.25
p.R966W	TCGA-EJ-5530	PRAD	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.R966W	DO36264	PRAD	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.P982L	TCGA-EY-A2OM	UCEC	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.1389
p.P982L	DO43025	UCEC	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.1389
p.R977T	TCGA-GD-A6C6	BLCA	TCGA	LYLYKD	LIG_APCC_ABBA_1	0.2778
p.R977T	DO48504	BLCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.2778
p.V963I	DO52481	COCA	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.1389
p.Q979K	DO228952	LICA	ICGC	LYLYKD	LIG_APCC_ABBA_1	0.2222
p.Y971C	SIDM01097	Other Solid Cancers	GDSC	LYLYKD	LIG_APCC_ABBA_1	0.5976
p.Y971C	SK-PN-DW	bone	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.5976
p.Y961C	SK-PN-DW	bone	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.0833
p.S975N	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.7069
p.S976N	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.3056
p.A983P	NCI-H650	lung	COSMIC	LYLYKD	LIG_APCC_ABBA_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	LIG_APCC_ABBA_1	970:975	LYLYKD	APC,CDC20,FZR1	0.5903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LYLYKD

Degron related mutations and impact score

Drug responses associated with ARHGAP21 mutations

All proteins holding degron of LYLYKD