DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_APCC_DBOX_1

Location: 614:622

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 99.2

COIL: 0.8432

CONS_SCORE: 0.3221

DSS_SCORE: 0.5575

HELIX: 0.0721

FCONS_SCORE: 1.0702

RIG_SCORE: 0.7296

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I615M	DIFI	large_intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.7618
p.S625Y	TCGA-AJ-A3EK	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	TCGA-AX-A05Z	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	TCGA-EY-A1GI	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO40884	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO41584	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO41211	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.R622Q	DO52432	COCA	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6218
p.V623I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.3056
p.R609Q	TCGA-BR-8361	STAD	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	DO48032	STAD	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00194	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00557	Neuroblastoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00216	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00600	Thyroid Gland Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00281	Other Solid Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00530	Esophageal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00596	Endometrial Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00018	Acute Myeloid Leukemia	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01217	Other Blood Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944

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Drug responses associated with ARHGAP21 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DRSPLVKVR

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_DBOX_1	614:622	DRSPLVKVR	APC,CDC20,FZR1	0.9869	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRSPLVKVR

Degron related mutations and impact score

Drug responses associated with ARHGAP21 mutations

All proteins holding degron of DRSPLVKVR