DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_APCC_DBOX_1

Location: 614:622

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 99.2

COIL: 0.8432

CONS_SCORE: 0.3221

DSS_SCORE: 0.5575

HELIX: 0.0721

FCONS_SCORE: 1.0702

RIG_SCORE: 0.7296

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S625Y	TCGA-AJ-A3EK	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	TCGA-AX-A05Z	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	TCGA-EY-A1GI	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO40884	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO41584	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.S625Y	DO41211	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6944
p.R609Q	TCGA-BR-8361	STAD	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	DO48032	STAD	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00194	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00557	Neuroblastoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00216	Colorectal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00600	Thyroid Gland Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00281	Other Solid Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00530	Esophageal Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00596	Endometrial Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00018	Acute Myeloid Leukemia	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01217	Other Blood Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00543	Melanoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM00302	Other Solid Cancers	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01449	Pancreatic Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01570	Ovarian Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01622	Breast Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01368	Gastric Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01432	Kidney Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01435	Hepatocellular Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.R609Q	SIDM01343	Gastric Carcinoma	GDSC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1944
p.H632Y	TCGA-D1-A160	UCEC	TCGA	DRSPLVKVR	DEG_APCC_DBOX_1	0.0556
p.H632Y	DO41626	UCEC	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.0556
p.R622Q	DO52432	COCA	ICGC	DRSPLVKVR	DEG_APCC_DBOX_1	0.6218
p.P630H	AN3-CA	endometrium	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1111
p.V623I	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.3056
p.R607Q	NCI-H630	large_intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1389
p.R608Q	NCI-H630	large_intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.1667
p.I615M	DIFI	large_intestine	COSMIC	DRSPLVKVR	DEG_APCC_DBOX_1	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRSPLVKVR

Degron related mutations and impact score

Drug responses associated with ARHGAP21 mutations

All proteins holding degron of DRSPLVKVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_DBOX_1	614:622	DRSPLVKVR	APC,CDC20,FZR1	0.9869	More...