DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_APCC_KENBOX_2

Location: 1443:1447

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 111.28

COIL: 0.612

CONS_SCORE: 0.3196

DSS_SCORE: 0.5205

HELIX: 0.3448

FCONS_SCORE: 1.0346

RIG_SCORE: 0.7266

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1442V	TCGA-B5-A11N	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.3056
p.F1442V	DO41458	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.3056
p.K1443N	TCGA-B5-A1MX	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.5806
p.K1443N	DO41999	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.5806
p.N1452S	TCGA-DF-A2KN	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1944
p.N1452S	DO223282	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1944
p.N1452S	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	0.1944
p.N1452S	ACH-000438	Lung Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	0.1944
p.N1452S	LU-65	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.1944
p.E1436K	TCGA-XF-AAN0	BLCA	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1389
p.E1436K	DO51941	BLCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1389
p.Q1449K	DO229026	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.2778
p.N1446S	DO34088	PACA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1443:1447	KKENV	APC,CDC20,FZR1	0.981	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	61:65	KKENV	APC,CDC20,FZR1	0.9305	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_KENBOX_2	3973:3977	KKENV	APC,CDC20,FZR1	0.9034	More...
Q9UBT6	DNA polymerase kappa	DEG_APCC_KENBOX_2	671:675	KKENV	APC,CDC20,FZR1	0.755	More...
Q3MJ40	Coiled-coil domain-containing protein 144B	DEG_APCC_KENBOX_2	517:521	KKENV	APC,CDC20,FZR1	0.5338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons