DegronMD - Q9UBT6(POLK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G510S	TCGA-A3-3382	KIRC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.5882
p.N670S	TCGA-B5-A0JR	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.G510D	TCGA-CV-7421	HNSC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.6087
p.R512W	TCGA-E6-A1LX	UCEC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.7523
p.N518D	TCGA-F1-6177	STAD	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1667
p.I513M	TCGA-QH-A86X	LGG	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.3056
p.S498Y	DO48566	BLCA	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1667
p.S498Y	DO41458	UCEC	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.1667
p.F671L	DO10582	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.6981
p.D668Y	DO229027	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation substituting flanking lysine	0.3611
p.P501L	DO229177	LMS	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation rewiring degron network	0.25
p.P663L	DO232761	PBCA	ICGC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1111
p.D510Y	DO37643	SKCM	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	504:512	Mutation altering degron motif	0.7325
p.S678A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.25
p.C681R	SIDM01113	Other Sarcomas	GDSC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1667
p.C681R	ACH-000939	Sarcoma	CCLE	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1667
p.C681R	SK-UT-1	soft tissue	COSMIC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.1667
p.N670K	SIDM01770	Gastric Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.N670K	ACH-000908	Gastric Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.K672N	COR-L88	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.6918

Kaplan plot for POLK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLK

UniProt ID: Q9UBT6

Entrez ID: 51426

Protein name: DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLK in