DegronMD

Uniprot ID: Q9UBT6

Source protein: DNA polymerase kappa

Source gene: POLK

Class: DEG_APCC_DBOX_1

Location: 504:512

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7331

ASA_SCORE: 28.1333

COIL: 0.2751

CONS_SCORE: 0.5521

DSS_SCORE: 0.227

HELIX: 0.0307

FCONS_SCORE: 1.7444

RIG_SCORE: 0.806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G510S	TCGA-A3-3382	KIRC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	0.5882
p.G510D	TCGA-CV-7421	HNSC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	0.6087
p.R512W	TCGA-E6-A1LX	UCEC	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	0.7523
p.N518D	TCGA-F1-6177	STAD	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	0.1667
p.I513M	TCGA-QH-A86X	LGG	TCGA	LRLRLMGVR	DEG_APCC_DBOX_1	0.3056
p.S498Y	DO48566	BLCA	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	0.1667
p.S498Y	DO41458	UCEC	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	0.1667
p.P501L	DO229177	LMS	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	0.25
p.D510Y	DO37643	SKCM	ICGC	LRLRLMGVR	DEG_APCC_DBOX_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBT6	DNA polymerase kappa	DEG_APCC_DBOX_1	504:512	LRLRLMGVR	APC,CDC20,FZR1	0.7331	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons