DegronMD

Uniprot ID: Q9UBT6

Source protein: DNA polymerase kappa

Source gene: POLK

Class: DEG_APCC_KENBOX_2

Location: 671:675

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.755

ASA_SCORE: 121.36

COIL: 0.9272

CONS_SCORE: 0.2162

DSS_SCORE: 0.3207

HELIX: 0.0496

FCONS_SCORE: 1.0093

RIG_SCORE: 0.7158

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N670S	TCGA-B5-A0JR	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.3056
p.F671L	DO10582	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.6981
p.D668Y	DO229027	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.3611
p.P663L	DO232761	PBCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1111
p.S678A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	0.25
p.C681R	SIDM01113	Other Sarcomas	GDSC	KKENV	DEG_APCC_KENBOX_2	0.1667
p.C681R	ACH-000939	Sarcoma	CCLE	KKENV	DEG_APCC_KENBOX_2	0.1667
p.C681R	SK-UT-1	soft_tissue	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.1667
p.N670K	SIDM01770	Gastric Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	0.3056
p.N670K	ACH-000908	Gastric Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	0.3056
p.K672N	COR-L88	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1443:1447	KKENV	APC,CDC20,FZR1	0.981	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	61:65	KKENV	APC,CDC20,FZR1	0.9305	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_KENBOX_2	3973:3977	KKENV	APC,CDC20,FZR1	0.9034	More...
Q9UBT6	DNA polymerase kappa	DEG_APCC_KENBOX_2	671:675	KKENV	APC,CDC20,FZR1	0.755	More...
Q3MJ40	Coiled-coil domain-containing protein 144B	DEG_APCC_KENBOX_2	517:521	KKENV	APC,CDC20,FZR1	0.5338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons