DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_APCC_KENBOX_2

Location: 3973:3977

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9034

ASA_SCORE: 104.9

COIL: 0.8102

CONS_SCORE: 0.5396

DSS_SCORE: 0.5209

HELIX: 0.13

FCONS_SCORE: 1.2573

RIG_SCORE: 0.6915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3983C	TCGA-33-AASB	LUSC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1667
p.G3983V	TCGA-33-AASB	LUSC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1667
p.G3981D	TCGA-AX-A1C9	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.2222
p.G3981D	DO43098	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.2222
p.E3974K	TCGA-Q1-A73O	CESC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.7022
p.E3974K	DO51612	CESC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.7022
p.G3970S	DO8224	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.25
p.R3987K	DO229010	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO229013	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO229016	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO229003	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO229005	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO234285	ESAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.R3987K	DO229505	LAML	ICGC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.V3976M	DO233088	GACA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.7208
p.R3970I	DO229031	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.25
p.A3975T	DO46657	PAAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.7139
p.R3971W	DO41235	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.2778
p.R3971W	DO41331	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.2778
p.S3986F	SIDM00007	Other Solid Cancers	GDSC	KKENV	DEG_APCC_KENBOX_2	0.0833
p.S3986F	MCC13	skin	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.0833
p.V3963A	SIDM00683	Prostate Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.V3963A	LNCaP-Clone-FGC	prostate	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.0556
p.S3985F	ACH-001550	Skin Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	0.1111
p.G3971S	HEC-1	endometrium	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.2778
p.G3971C	NCI-H1703	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1443:1447	KKENV	APC,CDC20,FZR1	0.981	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	61:65	KKENV	APC,CDC20,FZR1	0.9305	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_KENBOX_2	3973:3977	KKENV	APC,CDC20,FZR1	0.9034	More...
Q9UBT6	DNA polymerase kappa	DEG_APCC_KENBOX_2	671:675	KKENV	APC,CDC20,FZR1	0.755	More...
Q3MJ40	Coiled-coil domain-containing protein 144B	DEG_APCC_KENBOX_2	517:521	KKENV	APC,CDC20,FZR1	0.5338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENV

Degron related mutations and impact score

Drug responses associated with ALMS1 mutations

All proteins holding degron of KKENV