DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_APCC_KENBOX_2

Location: 61:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9305

ASA_SCORE: 117.58

COIL: 0.8138

CONS_SCORE: 0.5109

DSS_SCORE: 0.6597

HELIX: 0.1282

FCONS_SCORE: 1.0226

RIG_SCORE: 0.6702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A70T	TCGA-AP-A1DV	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1944
p.A70T	DO43186	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1944
p.A70T	ACH-000920	Leukemia	CCLE	KKENV	DEG_APCC_KENBOX_2	0.1944
p.R71K	TCGA-AP-A1DV	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1667
p.R71K	DO43186	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1667
p.A68T	TCGA-AZ-6607	COAD	TCGA	KKENV	DEG_APCC_KENBOX_2	0.6944
p.A68T	DO8522	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.6944
p.R71T	TCGA-CD-5813	STAD	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1667
p.R71T	DO38259	STAD	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1667
p.E54D	TCGA-D1-A3DA	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1389
p.E54D	DO229026	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1389
p.E54D	DO43258	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1389
p.T73I	TCGA-EE-A2GH	SKCM	TCGA	KKENV	DEG_APCC_KENBOX_2	0.1111
p.T73I	DO37643	SKCM	ICGC	KKENV	DEG_APCC_KENBOX_2	0.1111
p.S67P	DO229213	THCA	ICGC	KKENV	DEG_APCC_KENBOX_2	0.7222
p.S75F	ACH-000578	Lung Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1443:1447	KKENV	APC,CDC20,FZR1	0.981	More...
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	61:65	KKENV	APC,CDC20,FZR1	0.9305	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_KENBOX_2	3973:3977	KKENV	APC,CDC20,FZR1	0.9034	More...
Q9UBT6	DNA polymerase kappa	DEG_APCC_KENBOX_2	671:675	KKENV	APC,CDC20,FZR1	0.755	More...
Q3MJ40	Coiled-coil domain-containing protein 144B	DEG_APCC_KENBOX_2	517:521	KKENV	APC,CDC20,FZR1	0.5338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons