DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KKENV
Uniprot ID:
Q3MJ40
Source protein:
Coiled-coil domain-containing protein 144B
Source gene:
CCDC144B
Class:
DEG_APCC_KENBOX_2
Location:
517:521
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5338
ASA_SCORE:
121.88
COIL:
0.4522
CONS_SCORE:
0.9834
DSS_SCORE:
0.3942
HELIX:
0.5476
FCONS_SCORE:
1.3338
RIG_SCORE:
0.7665
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC144B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KKENV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T5U3
Rho GTPase-activating protein 21
DEG_APCC_KENBOX_2
1443:1447
KKENV
APC,CDC20,FZR1
0.981
More...
Q68DQ2
Very large A-kinase anchor protein
DEG_APCC_KENBOX_2
61:65
KKENV
APC,CDC20,FZR1
0.9305
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_APCC_KENBOX_2
3973:3977
KKENV
APC,CDC20,FZR1
0.9034
More...
Q9UBT6
DNA polymerase kappa
DEG_APCC_KENBOX_2
671:675
KKENV
APC,CDC20,FZR1
0.755
More...
Q3MJ40
Coiled-coil domain-containing protein 144B
DEG_APCC_KENBOX_2
517:521
KKENV
APC,CDC20,FZR1
0.5338
More...