DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_SCF_TRCP1_1

Location: 1545:1551

E3 ligase: BTRC

DEGRON score: 0.9532

ASA_SCORE: 80.3714

COIL: 0.8066

CONS_SCORE: 0.3077

DSS_SCORE: 0.5374

HELIX: 0.1614

FCONS_SCORE: 0.9774

RIG_SCORE: 0.6386

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1555R	TCGA-21-1077	LUSC	TCGA	DSGTLLS	DEG_SCF_TRCP1_1	0.2222
p.Q1555R	DO26725	LUSC	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	0.2222
p.S1544Y	TCGA-EE-A3AD	SKCM	TCGA	DSGTLLS	DEG_SCF_TRCP1_1	0.3056
p.S1544Y	DO37707	SKCM	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	0.3056
p.L1550I	DO229018	LICA	ICGC	DSGTLLS	DEG_SCF_TRCP1_1	0.6063
p.S1546P	SIDM01463	Endometrial Carcinoma	GDSC	DSGTLLS	DEG_SCF_TRCP1_1	0.6752
p.S1546P	ACH-000397	Endometrial/Uterine Cancer	CCLE	DSGTLLS	DEG_SCF_TRCP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_SCF_TRCP1_1	1545:1551	DSGTLLS	BTRC	0.9532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons