DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_COP1_1

Location: 829:838

E3 ligase: COP1

DEGRON score: 0.8651

ASA_SCORE: 77.41

COIL: 0.8653

CONS_SCORE: 0.3678

DSS_SCORE: 0.3275

HELIX: 0.0693

FCONS_SCORE: 1.009

RIG_SCORE: 0.6908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P836H	TCGA-BH-A203	BRCA	TCGA	SASTSQVPSI	DEG_COP1_1	0.7694
p.P836H	TCGA-EE-A2M6	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	0.7694
p.P836H	DO2156	BRCA	ICGC	SASTSQVPSI	DEG_COP1_1	0.7694
p.P836H	DO37976	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	0.7694
p.P823S	TCGA-EE-A181	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	0.1667
p.P823S	DO37444	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	0.1667
p.P843T	TCGA-EE-A2GR	SKCM	TCGA	SASTSQVPSI	DEG_COP1_1	0.1944
p.P843T	DO37996	SKCM	ICGC	SASTSQVPSI	DEG_COP1_1	0.1944
p.C844S	DO228950	LICA	ICGC	SASTSQVPSI	DEG_COP1_1	0.1667
p.Q834H	DO229229	THCA	ICGC	SASTSQVPSI	DEG_COP1_1	0.647
p.I828M	SIDM00049	Colorectal Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	0.3056
p.I828M	ACH-002233	Colon/Colorectal Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	0.3056
p.I828M	DIFI	large_intestine	COSMIC	SASTSQVPSI	DEG_COP1_1	0.3056
p.T846K	SIDM00485	Oral Cavity Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	0.1111
p.T846K	ACH-000794	Head and Neck Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	0.1111
p.T846K	BICR22	upper_aerodigestive_tract	COSMIC	SASTSQVPSI	DEG_COP1_1	0.1111
p.P843H	SIDM00901	Endometrial Carcinoma	GDSC	SASTSQVPSI	DEG_COP1_1	0.1944
p.P843H	ACH-000940	Endometrial/Uterine Cancer	CCLE	SASTSQVPSI	DEG_COP1_1	0.1944
p.P843H	AN3-CA	endometrium	COSMIC	SASTSQVPSI	DEG_COP1_1	0.1944
p.A830T	ACH-001991	Primary	CCLE	SASTSQVPSI	DEG_COP1_1	0.6028
p.R843H	VMRC-RCW	kidney	COSMIC	SASTSQVPSI	DEG_COP1_1	0.1944
p.R843H	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	SASTSQVPSI	DEG_COP1_1	0.1944
p.T836K	BICR22	upper_aerodigestive_tract	COSMIC	SASTSQVPSI	DEG_COP1_1	0.7306
p.P833H	AN3-CA	endometrium	COSMIC	SASTSQVPSI	DEG_COP1_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_COP1_1	829:838	SASTSQVPSI	COP1	0.8651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons