DegronMD

Uniprot ID: Q5T5U3

Source protein: Rho GTPase-activating protein 21

Source gene: ARHGAP21

Class: DEG_APCC_KENBOX_2

Location: 1474:1478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8676

ASA_SCORE: 109.3

COIL: 0.7918

CONS_SCORE: 0.3206

DSS_SCORE: 0.6139

HELIX: 0.17

FCONS_SCORE: 1.0232

RIG_SCORE: 0.6976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1467K	TCGA-56-8625	LUSC	TCGA	AKENS	DEG_APCC_KENBOX_2	0.1389
p.R1467K	DO45515	LUSC	ICGC	AKENS	DEG_APCC_KENBOX_2	0.1389
p.D1482H	TCGA-A8-A0A9	BRCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2222
p.D1482H	DO2473	BRCA	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2222
p.I1472V	TCGA-G4-6322	COAD	TCGA	AKENS	DEG_APCC_KENBOX_2	0.2778
p.I1472V	DO8439	COAD	ICGC	AKENS	DEG_APCC_KENBOX_2	0.2778
p.I1471V	TCGA-LN-A49R	ESCA	TCGA	AKENS	DEG_APCC_KENBOX_2	0.25
p.S1484I	SIDM00373	Endometrial Carcinoma	GDSC	AKENS	DEG_APCC_KENBOX_2	0.1667
p.S1484I	ACH-000974	Endometrial/Uterine Cancer	CCLE	AKENS	DEG_APCC_KENBOX_2	0.1667
p.T1485M	ACH-000937	Leukemia	CCLE	AKENS	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5U3	Rho GTPase-activating protein 21	DEG_APCC_KENBOX_2	1474:1478	AKENS	APC,CDC20,FZR1	0.8676	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_APCC_KENBOX_2	110:114	AKENS	APC,CDC20,FZR1	0.6159	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	484:488	AKENS	APC,CDC20,FZR1	0.9942	More...
Q9C0A6	Histone-lysine N-methyltransferase SETD5	DEG_APCC_KENBOX_2	1078:1082	AKENS	APC,CDC20,FZR1	0.5556	More...
Q9UHV9	Prefoldin subunit 2	DEG_APCC_KENBOX_2	135:139	AKENS	APC,CDC20,FZR1	0.6125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons